@article{1b2a395a261f4db8b293379ca23c42bf,
title = "Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor",
abstract = "Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation–contraction (E–C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.",
keywords = "Calcium, Excitation–contraction coupling, Muscular dystrophy, RyR1, Skeletal muscle",
author = "Gaetano Santulli and Lewis, {Daniel R.} and Marks, {Andrew R.}",
note = "Funding Information: Acknowledgements The studies described in this review were supported by NIH grants (R01AR060037 and R01HL061503) and the Fondation Leducq to A.R.M. G.S. is supported by the NIH (K99DK107895). ARM is a consultant and member of the board of ARMGO Pharma that is targeting RyR channels for therapeutic purposes. The Authors thank Ran Zalk, Amedee des Georges, Oliver Clarke, Wayne Hendrickson and Joachim Frank who conducted the structural studies with A.R.M., and members of the Marks laboratory who have performed many of the studies described herein over the past 27 years.",
year = "2017",
month = feb,
day = "1",
doi = "10.1007/s10974-017-9470-z",
language = "English (US)",
volume = "38",
pages = "37--45",
journal = "Journal of Muscle Research and Cell Motility",
issn = "0142-4319",
publisher = "Springer Netherlands",
number = "1",
}