Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor

Gaetano Santulli; Daniel R. Lewis; Andrew R. Marks

doi:10.1007/s10974-017-9470-z

Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor

Gaetano Santulli, Daniel R. Lewis, Andrew R. Marks

Medicine

Research output: Contribution to journal › Article

18 Scopus citations

Abstract

Calcium (Ca²⁺) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca²⁺ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation–contraction (E–C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.

Original language	English (US)
Pages (from-to)	37-45
Number of pages	9
Journal	Journal of Muscle Research and Cell Motility
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/s10974-017-9470-z
State	Published - Feb 1 2017

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Keywords

Calcium
Excitation–contraction coupling
Muscular dystrophy
RyR1
Skeletal muscle

ASJC Scopus subject areas

Biochemistry
Physiology
Cell Biology

Cite this

Santulli, G., Lewis, D. R., & Marks, A. R. (2017). Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor. Journal of Muscle Research and Cell Motility, 38(1), 37-45. https://doi.org/10.1007/s10974-017-9470-z

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10.1007/s10974-017-9470-z