Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor

Gaetano Santulli, Daniel R. Lewis, Andrew R. Marks

Research output: Contribution to journalArticle

18 Scopus citations


Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation–contraction (E–C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.

Original languageEnglish (US)
Pages (from-to)37-45
Number of pages9
JournalJournal of Muscle Research and Cell Motility
Issue number1
StatePublished - Feb 1 2017



  • Calcium
  • Excitation–contraction coupling
  • Muscular dystrophy
  • RyR1
  • Skeletal muscle

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cell Biology

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