Abstract
Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation–contraction (E–C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 37-45 |
| Number of pages | 9 |
| Journal | Journal of Muscle Research and Cell Motility |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2017 |
| Externally published | Yes |
Keywords
- Calcium
- Excitation–contraction coupling
- Muscular dystrophy
- RyR1
- Skeletal muscle
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Cell Biology
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Cite this
Santulli, G., Lewis, D. R., & Marks, A. R. (2017). Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor. Journal of Muscle Research and Cell Motility, 38(1), 37-45. https://doi.org/10.1007/s10974-017-9470-z