Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor

Gaetano Santulli; Daniel R. Lewis; Andrew R. Marks

doi:10.1007/s10974-017-9470-z

Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor

Gaetano Santulli, Daniel R. Lewis, Andrew R. Marks

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Calcium (Ca²⁺) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca²⁺ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation–contraction (E–C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.

Original language	English (US)
Pages (from-to)	37-45
Number of pages	9
Journal	Journal of Muscle Research and Cell Motility
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/s10974-017-9470-z
State	Published - Feb 1 2017
Externally published	Yes

Keywords

Calcium
Excitation–contraction coupling
Muscular dystrophy
RyR1
Skeletal muscle

ASJC Scopus subject areas

Physiology
Biochemistry
Cell Biology

Access to Document

10.1007/s10974-017-9470-z

Cite this

@article{1b2a395a261f4db8b293379ca23c42bf,

title = "Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor",

abstract = "Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation–contraction (E–C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.",

keywords = "Calcium, Excitation–contraction coupling, Muscular dystrophy, RyR1, Skeletal muscle",

author = "Gaetano Santulli and Lewis, {Daniel R.} and Marks, {Andrew R.}",

note = "Publisher Copyright: {\textcopyright} 2017, Springer International Publishing Switzerland.",

year = "2017",

month = feb,

day = "1",

doi = "10.1007/s10974-017-9470-z",

language = "English (US)",

volume = "38",

pages = "37--45",

journal = "Journal of Muscle Research and Cell Motility",

issn = "0142-4319",

publisher = "Springer Netherlands",

number = "1",

}

TY - JOUR

T1 - Physiology and pathophysiology of excitation–contraction coupling

T2 - the functional role of ryanodine receptor

AU - Santulli, Gaetano

AU - Lewis, Daniel R.

AU - Marks, Andrew R.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation–contraction (E–C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.

AB - Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation–contraction (E–C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.

KW - Calcium

KW - Excitation–contraction coupling

KW - Muscular dystrophy

KW - RyR1

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=85019997507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019997507&partnerID=8YFLogxK

U2 - 10.1007/s10974-017-9470-z

DO - 10.1007/s10974-017-9470-z

M3 - Article

C2 - 28653141

AN - SCOPUS:85019997507

SN - 0142-4319

VL - 38

SP - 37

EP - 45

JO - Journal of Muscle Research and Cell Motility

JF - Journal of Muscle Research and Cell Motility

IS - 1

ER -

Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this