Physiological Responses to Brain Stimulation During Limbic Surgery: Further Evidence of Anterior Cingulate Modulation of Autonomic Arousal

André Felix Gentil, Emad N. Eskandar, Carl David Marci, Karleyton Conroy Evans, Darin Dean Dougherty

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: In view of conflicting neuroimaging results regarding autonomic-specific activity within the anterior cingulate cortex (ACC), we investigated autonomic responses to direct brain stimulation during stereotactic limbic surgery. Methods: Skin conductance activity and accelerative heart rate responses to multi-voltage stimulation of the ACC (n = 7) and paralimbic subcaudate (n = 5) regions were recorded during bilateral anterior cingulotomy and bilateral subcaudate tractotomy (in patients that had previously received an adequate lesion in the ACC), respectively. Results: Stimulations in both groups were accompanied by increased autonomic arousal. Skin conductance activity was significantly increased during ACC stimulations compared with paralimbic targets at 2 V (2.34 ± .68 [score in microSiemens ± SE] vs. .34 ± .09, p = .013) and 3 V (3.52 ± .86 vs. 1.12 ± .37, p = .036), exhibiting a strong "voltage-response" relationship between stimulus magnitude and response amplitude (difference from 1 to 3 V = 1.15 ± .90 vs. 3.52 ± .86, p = .041). Heart rate response was less indicative of between-group differences. Conclusions: This is the first study of its kind aiming at seeking novel insights into the mechanisms responsible for central autonomic modulation. It supports a concept that interregional interactions account for the coordination of autonomic arousal.

Original languageEnglish (US)
Pages (from-to)695-701
Number of pages7
JournalBiological Psychiatry
Volume66
Issue number7
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Fingerprint

Gyrus Cinguli
Arousal
Brain
Heart Rate
Skin
Neuroimaging

Keywords

  • Anterior cingulotomy
  • autonomic nervous system
  • cingulate cortex
  • electrodermal activity
  • subcaudate tractotomy

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Physiological Responses to Brain Stimulation During Limbic Surgery : Further Evidence of Anterior Cingulate Modulation of Autonomic Arousal. / Gentil, André Felix; Eskandar, Emad N.; Marci, Carl David; Evans, Karleyton Conroy; Dougherty, Darin Dean.

In: Biological Psychiatry, Vol. 66, No. 7, 01.10.2009, p. 695-701.

Research output: Contribution to journalArticle

Gentil, André Felix ; Eskandar, Emad N. ; Marci, Carl David ; Evans, Karleyton Conroy ; Dougherty, Darin Dean. / Physiological Responses to Brain Stimulation During Limbic Surgery : Further Evidence of Anterior Cingulate Modulation of Autonomic Arousal. In: Biological Psychiatry. 2009 ; Vol. 66, No. 7. pp. 695-701.
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