Abstract
Background: In view of conflicting neuroimaging results regarding autonomic-specific activity within the anterior cingulate cortex (ACC), we investigated autonomic responses to direct brain stimulation during stereotactic limbic surgery. Methods: Skin conductance activity and accelerative heart rate responses to multi-voltage stimulation of the ACC (n = 7) and paralimbic subcaudate (n = 5) regions were recorded during bilateral anterior cingulotomy and bilateral subcaudate tractotomy (in patients that had previously received an adequate lesion in the ACC), respectively. Results: Stimulations in both groups were accompanied by increased autonomic arousal. Skin conductance activity was significantly increased during ACC stimulations compared with paralimbic targets at 2 V (2.34 ± .68 [score in microSiemens ± SE] vs. .34 ± .09, p = .013) and 3 V (3.52 ± .86 vs. 1.12 ± .37, p = .036), exhibiting a strong "voltage-response" relationship between stimulus magnitude and response amplitude (difference from 1 to 3 V = 1.15 ± .90 vs. 3.52 ± .86, p = .041). Heart rate response was less indicative of between-group differences. Conclusions: This is the first study of its kind aiming at seeking novel insights into the mechanisms responsible for central autonomic modulation. It supports a concept that interregional interactions account for the coordination of autonomic arousal.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 695-701 |
| Number of pages | 7 |
| Journal | Biological Psychiatry |
| Volume | 66 |
| Issue number | 7 |
| DOIs | |
| State | Published - Oct 1 2009 |
| Externally published | Yes |
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Keywords
- Anterior cingulotomy
- autonomic nervous system
- cingulate cortex
- electrodermal activity
- subcaudate tractotomy
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
Physiological Responses to Brain Stimulation During Limbic Surgery : Further Evidence of Anterior Cingulate Modulation of Autonomic Arousal. / Gentil, André Felix; Eskandar, Emad N.; Marci, Carl David; Evans, Karleyton Conroy; Dougherty, Darin Dean.
In: Biological Psychiatry, Vol. 66, No. 7, 01.10.2009, p. 695-701.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physiological Responses to Brain Stimulation During Limbic Surgery
T2 - Further Evidence of Anterior Cingulate Modulation of Autonomic Arousal
AU - Gentil, André Felix
AU - Eskandar, Emad N.
AU - Marci, Carl David
AU - Evans, Karleyton Conroy
AU - Dougherty, Darin Dean
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Background: In view of conflicting neuroimaging results regarding autonomic-specific activity within the anterior cingulate cortex (ACC), we investigated autonomic responses to direct brain stimulation during stereotactic limbic surgery. Methods: Skin conductance activity and accelerative heart rate responses to multi-voltage stimulation of the ACC (n = 7) and paralimbic subcaudate (n = 5) regions were recorded during bilateral anterior cingulotomy and bilateral subcaudate tractotomy (in patients that had previously received an adequate lesion in the ACC), respectively. Results: Stimulations in both groups were accompanied by increased autonomic arousal. Skin conductance activity was significantly increased during ACC stimulations compared with paralimbic targets at 2 V (2.34 ± .68 [score in microSiemens ± SE] vs. .34 ± .09, p = .013) and 3 V (3.52 ± .86 vs. 1.12 ± .37, p = .036), exhibiting a strong "voltage-response" relationship between stimulus magnitude and response amplitude (difference from 1 to 3 V = 1.15 ± .90 vs. 3.52 ± .86, p = .041). Heart rate response was less indicative of between-group differences. Conclusions: This is the first study of its kind aiming at seeking novel insights into the mechanisms responsible for central autonomic modulation. It supports a concept that interregional interactions account for the coordination of autonomic arousal.
AB - Background: In view of conflicting neuroimaging results regarding autonomic-specific activity within the anterior cingulate cortex (ACC), we investigated autonomic responses to direct brain stimulation during stereotactic limbic surgery. Methods: Skin conductance activity and accelerative heart rate responses to multi-voltage stimulation of the ACC (n = 7) and paralimbic subcaudate (n = 5) regions were recorded during bilateral anterior cingulotomy and bilateral subcaudate tractotomy (in patients that had previously received an adequate lesion in the ACC), respectively. Results: Stimulations in both groups were accompanied by increased autonomic arousal. Skin conductance activity was significantly increased during ACC stimulations compared with paralimbic targets at 2 V (2.34 ± .68 [score in microSiemens ± SE] vs. .34 ± .09, p = .013) and 3 V (3.52 ± .86 vs. 1.12 ± .37, p = .036), exhibiting a strong "voltage-response" relationship between stimulus magnitude and response amplitude (difference from 1 to 3 V = 1.15 ± .90 vs. 3.52 ± .86, p = .041). Heart rate response was less indicative of between-group differences. Conclusions: This is the first study of its kind aiming at seeking novel insights into the mechanisms responsible for central autonomic modulation. It supports a concept that interregional interactions account for the coordination of autonomic arousal.
KW - Anterior cingulotomy
KW - autonomic nervous system
KW - cingulate cortex
KW - electrodermal activity
KW - subcaudate tractotomy
UR - http://www.scopus.com/inward/record.url?scp=69749101256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69749101256&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2009.05.009
DO - 10.1016/j.biopsych.2009.05.009
M3 - Article
C2 - 19545859
AN - SCOPUS:69749101256
VL - 66
SP - 695
EP - 701
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 7
ER -