Physical decline and cognitive impairment in frail hypertensive elders during COVID-19

Pasquale Mone, Antonella Pansini, Salvatore Frullone, Antonio de Donato, Veronica Buonincontri, Paolo De Blasiis, Anna Marro, Maria Morgante, Antonio De Luca, Gaetano Santulli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Hypertension is common in older adults and its incidence increases with age. We investigated the correlation between physical and cognitive impairment in older adults with frailty and hypertension. Methods: We recruited frail hypertensive older adults during the COVID-19 pandemic, between March 2021 and December 2021. Global cognitive function was assessed through the Montreal Cognitive Assessment (MoCA), physical frailty assessment was performed following the Fried criteria, and all patients underwent physical evaluation through 5-meter gait speed test. Results: We enrolled 203 frail hypertensive older adults and we found a significant correlation between MoCA score and gait speed test (r: 0.495; p<0.001) in our population. To evaluate the impact of comorbidities and other factors on our results, we applied a linear regression analysis with MoCA score as a dependent variable, observing a significant association with age, diabetes, chronic obstructive pulmonary disease (COPD), and gait speed test. Conclusions: Our study revealed for the first time a significant correlation between physical and cognitive impairment in frail hypertensive elderly subjects.

Original languageEnglish (US)
JournalEuropean Journal of Internal Medicine
DOIs
StateAccepted/In press - 2022

Keywords

  • COVID-19
  • Cognitive impairment
  • Frailty
  • Hypertension
  • MoCA
  • Physical decline

ASJC Scopus subject areas

  • Internal Medicine

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