Physical activity and right ventricular structure and function: The MESA-right ventricle study

Carrie P. Aaron, Harikrishna Tandri, R. Graham Barr, W. Craig Johnson, Emilia Bagiella, Harjit Chahal, Aditya Jain, Jorge R. Kizer, Alain G. Bertoni, João A.C. Lima, David A. Bluemke, Steven M. Kawut

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Rationale: Intense exercise in elite athletes is associated with increased left ventricular (LV) and right ventricular (RV) mass and volumes. However,the effect of physical activity on the RV in an older community-based population is unknown. Objectives: We studied the association between levels of physical activity in adults and RV mass and volumes. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on community-based participants without clinical cardiovascular disease. RV volumes were determined from manually contoured endocardial margins. RV mass was determined from the difference between epicardial and endocardial volumes multiplied by the specific gravity of myocardium. Metabolic equivalent-minutes/ day were calculated from the self-reported frequency, duration, and intensity of physical activity. Measurements and Main Results: The study sample (n=1,867) was aged 61.8 ± 10 years, 48% male, 44% white, 27% African American, 20% Hispanic, and 9% Chinese. Higher levels of moderate and vigorous physical activity were linearly associated with higher RV mass (P=0.02) after adjusting for demographics, anthropometrics, smoking, cholesterol, diabetes mellitus, hypertension, and LV mass. Higher levels of intentional exercise (physical activity done for the sole purpose of conditioning or fitness) were nonlinearly associated with RV mass independent of LV mass (P = 0.03). There were similar associations between higher levels of physical activity and larger RV volumes. Conclusions: Higher levels of physical activity in adults were associated with greater RV mass independent of the associations with LV mass; similar results were found for RV volumes. Exercise-associated RV remodelingmay have important clinical implications.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume183
Issue number3
DOIs
StatePublished - Feb 1 2011

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Keywords

  • Exercise
  • Magnetic resonance imaging
  • Pulmonary heart disease
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Aaron, C. P., Tandri, H., Barr, R. G., Johnson, W. C., Bagiella, E., Chahal, H., Jain, A., Kizer, J. R., Bertoni, A. G., Lima, J. A. C., Bluemke, D. A., & Kawut, S. M. (2011). Physical activity and right ventricular structure and function: The MESA-right ventricle study. American Journal of Respiratory and Critical Care Medicine, 183(3), 396-404. https://doi.org/10.1164/rccm.201003-0469OC