Photocontrol of neural activity: Biophysical mechanisms and performance in vivo

Lucas L. Sjulson, Gero Miesenböck

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

A discussion regarding the various photomanipulation technologies demonstrated in the nervous system is given with a focus on the biophysical mechanisms and with their limitations with its performance. Topics being reviewed include photoablation and photoinactivation as well as the photomanipulation of membrane potential. Under photoablation and photoinactivation are more specific topics which include: the cellular targets with dye-mediated photoablation and the genetically targeted small molecule photoablation. As for molecular targets, the chromophore-assisted light inactivation (CALI) will be used. Under photomanipulation of membrane potential, topics that will be described will include: the role of ion-selective conductances; the effect of background synaptic activity; the thermal photostimulation; the reactive oxygen species-mediated photostimulation; the caged glutamate and GABA; and finally, the genetically encoded photomodulators of membrane potential.

Original languageEnglish (US)
Pages (from-to)1588-1602
Number of pages15
JournalChemical Reviews
Volume108
Issue number5
DOIs
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

Membranes
Neurology
Chromophores
gamma-Aminobutyric Acid
Glutamic Acid
Reactive Oxygen Species
Coloring Agents
Ions
Molecules
Hot Temperature

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Photocontrol of neural activity : Biophysical mechanisms and performance in vivo. / Sjulson, Lucas L.; Miesenböck, Gero.

In: Chemical Reviews, Vol. 108, No. 5, 01.05.2008, p. 1588-1602.

Research output: Contribution to journalReview article

@article{da1dd306d7084c8ba49dd0834f68252c,
title = "Photocontrol of neural activity: Biophysical mechanisms and performance in vivo",
abstract = "A discussion regarding the various photomanipulation technologies demonstrated in the nervous system is given with a focus on the biophysical mechanisms and with their limitations with its performance. Topics being reviewed include photoablation and photoinactivation as well as the photomanipulation of membrane potential. Under photoablation and photoinactivation are more specific topics which include: the cellular targets with dye-mediated photoablation and the genetically targeted small molecule photoablation. As for molecular targets, the chromophore-assisted light inactivation (CALI) will be used. Under photomanipulation of membrane potential, topics that will be described will include: the role of ion-selective conductances; the effect of background synaptic activity; the thermal photostimulation; the reactive oxygen species-mediated photostimulation; the caged glutamate and GABA; and finally, the genetically encoded photomodulators of membrane potential.",
author = "Sjulson, {Lucas L.} and Gero Miesenb{\"o}ck",
year = "2008",
month = "5",
day = "1",
doi = "10.1021/cr078221b",
language = "English (US)",
volume = "108",
pages = "1588--1602",
journal = "Chemical Reviews",
issn = "0009-2665",
publisher = "American Chemical Society",
number = "5",

}

TY - JOUR

T1 - Photocontrol of neural activity

T2 - Biophysical mechanisms and performance in vivo

AU - Sjulson, Lucas L.

AU - Miesenböck, Gero

PY - 2008/5/1

Y1 - 2008/5/1

N2 - A discussion regarding the various photomanipulation technologies demonstrated in the nervous system is given with a focus on the biophysical mechanisms and with their limitations with its performance. Topics being reviewed include photoablation and photoinactivation as well as the photomanipulation of membrane potential. Under photoablation and photoinactivation are more specific topics which include: the cellular targets with dye-mediated photoablation and the genetically targeted small molecule photoablation. As for molecular targets, the chromophore-assisted light inactivation (CALI) will be used. Under photomanipulation of membrane potential, topics that will be described will include: the role of ion-selective conductances; the effect of background synaptic activity; the thermal photostimulation; the reactive oxygen species-mediated photostimulation; the caged glutamate and GABA; and finally, the genetically encoded photomodulators of membrane potential.

AB - A discussion regarding the various photomanipulation technologies demonstrated in the nervous system is given with a focus on the biophysical mechanisms and with their limitations with its performance. Topics being reviewed include photoablation and photoinactivation as well as the photomanipulation of membrane potential. Under photoablation and photoinactivation are more specific topics which include: the cellular targets with dye-mediated photoablation and the genetically targeted small molecule photoablation. As for molecular targets, the chromophore-assisted light inactivation (CALI) will be used. Under photomanipulation of membrane potential, topics that will be described will include: the role of ion-selective conductances; the effect of background synaptic activity; the thermal photostimulation; the reactive oxygen species-mediated photostimulation; the caged glutamate and GABA; and finally, the genetically encoded photomodulators of membrane potential.

UR - http://www.scopus.com/inward/record.url?scp=44849127933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44849127933&partnerID=8YFLogxK

U2 - 10.1021/cr078221b

DO - 10.1021/cr078221b

M3 - Review article

C2 - 18447399

AN - SCOPUS:44849127933

VL - 108

SP - 1588

EP - 1602

JO - Chemical Reviews

JF - Chemical Reviews

SN - 0009-2665

IS - 5

ER -