pH, EF-1α and the cytoskeleton

Gang Liu; Brian T. Edmonds; John Condeelis

doi:10.1016/0962-8924(96)20013-3

pH, EF-1α and the cytoskeleton

Gang Liu, Brian T. Edmonds, John Condeelis

Cell Biology

Research output: Contribution to journal › Comment/debate › peer-review

45 Scopus citations

Abstract

One of the unexpected cellular components found interacting with the cytoskeleton is elongation factor 1 alpha (EF-1α). How this interaction is regulated is not clear, but pH may be a potent regulator. Interestingly, pH also regulates the amount of protein translation occurring in many cell systems. In this paper, the authors suggest that sequestration of EF-1α in the cytoskeleton may play a key role in regulating the spatial distribution of macromolecular assembly in a way that is dependent on cytoplasmic pH.

Original language	English (US)
Pages (from-to)	168-171
Number of pages	4
Journal	Trends in Cell Biology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/0962-8924(96)20013-3
State	Published - May 1996

ASJC Scopus subject areas

Cell Biology

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10.1016/0962-8924(96)20013-3

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abstract = "One of the unexpected cellular components found interacting with the cytoskeleton is elongation factor 1 alpha (EF-1α). How this interaction is regulated is not clear, but pH may be a potent regulator. Interestingly, pH also regulates the amount of protein translation occurring in many cell systems. In this paper, the authors suggest that sequestration of EF-1α in the cytoskeleton may play a key role in regulating the spatial distribution of macromolecular assembly in a way that is dependent on cytoplasmic pH.",

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AB - One of the unexpected cellular components found interacting with the cytoskeleton is elongation factor 1 alpha (EF-1α). How this interaction is regulated is not clear, but pH may be a potent regulator. Interestingly, pH also regulates the amount of protein translation occurring in many cell systems. In this paper, the authors suggest that sequestration of EF-1α in the cytoskeleton may play a key role in regulating the spatial distribution of macromolecular assembly in a way that is dependent on cytoplasmic pH.

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pH, EF-1α and the cytoskeleton

Abstract

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