Perineurial cell tumor - Immunocytochemical and ultrastructural characterization. Relationship to other peripheral nerve tumors with a review of the literature

Karen M. Weidenheim, Wallace G. Campbell

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A perineurial cell tumor occurred in the shoulder girdle of a 47 year old woman. Light microscopy demonstrated a well-differentiated spindle-cell neoplasm of uncertain histogenesis. Immunocytochemical staining for S-100 protein was negative. Ultrastructural study revealed tumor cells with characteristics of perineurium, e.g. large numbers of micropinocytotic vesicles, numerous intercellular junctions, and elongated cell processes surrounded by basal lamina. Tumors of perineurial cells should be distinguished from the commonly recognized schwannomas as well as from various soft tissue lesions so that their biologic behavior can be better defined. A review of three other reported cases of perineurial cell tumors suggested that these tumors are benign and are usually located in the extremities and shoulder girdle. In addition, perineurial cell proliferation has been identified in other lesions of peripheral nerves, such as neurofibromas and localized hypertrophic neuropathy. Immunocytochemical and ultrastructural study of spindle-cell lesions with unusual histologic features may reveal that perineurial cell proliferation occurs more frequently than currently recognized.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Volume408
Issue number4
DOIs
StatePublished - Jul 1986
Externally publishedYes

Fingerprint

Peripheral Nervous System Neoplasms
Neoplasms
Peripheral Nerves
Cell Proliferation
Neurofibroma
Intercellular Junctions
S100 Proteins
Neurilemmoma
Basement Membrane
Microscopy
Extremities
Staining and Labeling
Light

Keywords

  • Nerve tissue protein S-100
  • Perineurial cell
  • Peripheral nerve diseases
  • Peripheral nerve neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

Cite this

@article{a672a1cb33f34300b8c23d9bf862efa4,
title = "Perineurial cell tumor - Immunocytochemical and ultrastructural characterization. Relationship to other peripheral nerve tumors with a review of the literature",
abstract = "A perineurial cell tumor occurred in the shoulder girdle of a 47 year old woman. Light microscopy demonstrated a well-differentiated spindle-cell neoplasm of uncertain histogenesis. Immunocytochemical staining for S-100 protein was negative. Ultrastructural study revealed tumor cells with characteristics of perineurium, e.g. large numbers of micropinocytotic vesicles, numerous intercellular junctions, and elongated cell processes surrounded by basal lamina. Tumors of perineurial cells should be distinguished from the commonly recognized schwannomas as well as from various soft tissue lesions so that their biologic behavior can be better defined. A review of three other reported cases of perineurial cell tumors suggested that these tumors are benign and are usually located in the extremities and shoulder girdle. In addition, perineurial cell proliferation has been identified in other lesions of peripheral nerves, such as neurofibromas and localized hypertrophic neuropathy. Immunocytochemical and ultrastructural study of spindle-cell lesions with unusual histologic features may reveal that perineurial cell proliferation occurs more frequently than currently recognized.",
keywords = "Nerve tissue protein S-100, Perineurial cell, Peripheral nerve diseases, Peripheral nerve neoplasms",
author = "Weidenheim, {Karen M.} and Campbell, {Wallace G.}",
year = "1986",
month = "7",
doi = "10.1007/BF00707695",
language = "English (US)",
volume = "408",
pages = "375--383",
journal = "Virchows Archiv",
issn = "0945-6317",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Perineurial cell tumor - Immunocytochemical and ultrastructural characterization. Relationship to other peripheral nerve tumors with a review of the literature

AU - Weidenheim, Karen M.

AU - Campbell, Wallace G.

PY - 1986/7

Y1 - 1986/7

N2 - A perineurial cell tumor occurred in the shoulder girdle of a 47 year old woman. Light microscopy demonstrated a well-differentiated spindle-cell neoplasm of uncertain histogenesis. Immunocytochemical staining for S-100 protein was negative. Ultrastructural study revealed tumor cells with characteristics of perineurium, e.g. large numbers of micropinocytotic vesicles, numerous intercellular junctions, and elongated cell processes surrounded by basal lamina. Tumors of perineurial cells should be distinguished from the commonly recognized schwannomas as well as from various soft tissue lesions so that their biologic behavior can be better defined. A review of three other reported cases of perineurial cell tumors suggested that these tumors are benign and are usually located in the extremities and shoulder girdle. In addition, perineurial cell proliferation has been identified in other lesions of peripheral nerves, such as neurofibromas and localized hypertrophic neuropathy. Immunocytochemical and ultrastructural study of spindle-cell lesions with unusual histologic features may reveal that perineurial cell proliferation occurs more frequently than currently recognized.

AB - A perineurial cell tumor occurred in the shoulder girdle of a 47 year old woman. Light microscopy demonstrated a well-differentiated spindle-cell neoplasm of uncertain histogenesis. Immunocytochemical staining for S-100 protein was negative. Ultrastructural study revealed tumor cells with characteristics of perineurium, e.g. large numbers of micropinocytotic vesicles, numerous intercellular junctions, and elongated cell processes surrounded by basal lamina. Tumors of perineurial cells should be distinguished from the commonly recognized schwannomas as well as from various soft tissue lesions so that their biologic behavior can be better defined. A review of three other reported cases of perineurial cell tumors suggested that these tumors are benign and are usually located in the extremities and shoulder girdle. In addition, perineurial cell proliferation has been identified in other lesions of peripheral nerves, such as neurofibromas and localized hypertrophic neuropathy. Immunocytochemical and ultrastructural study of spindle-cell lesions with unusual histologic features may reveal that perineurial cell proliferation occurs more frequently than currently recognized.

KW - Nerve tissue protein S-100

KW - Perineurial cell

KW - Peripheral nerve diseases

KW - Peripheral nerve neoplasms

UR - http://www.scopus.com/inward/record.url?scp=0022560235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022560235&partnerID=8YFLogxK

U2 - 10.1007/BF00707695

DO - 10.1007/BF00707695

M3 - Article

C2 - 3080843

AN - SCOPUS:0022560235

VL - 408

SP - 375

EP - 383

JO - Virchows Archiv

JF - Virchows Archiv

SN - 0945-6317

IS - 4

ER -