TY - JOUR
T1 - Penicillin-resistant Streptococcus pneumoniae in metropolitan New York hospitals
T2 - Case control study and molecular typing of resistant isolates
AU - Roberts, R. B.
AU - Tomasz, A.
AU - Corso, A.
AU - Hargrave, J.
AU - Severina, E.
AU - LaBombardi, V.
AU - Sampath, A.
AU - Mannheimer, S.
AU - Pringle, G.
AU - Rahal, J.
AU - Urban, C.
AU - Currie, B.
AU - Bartscher, J.
AU - Levi, M.
AU - Berger, J.
AU - Brown, S.
AU - Shahidi, A.
AU - Leggiadro, R.
AU - Hashem, M.
AU - Kopetz, V.
AU - Spitzer, E.
AU - Van Horn, K.
AU - Larone, D.
PY - 2001
Y1 - 2001
N2 - During the 4-month period from January to April, 1998, 476 patients with Streptococcus pneumoniae infections were detected in 12 metropolitan New York hospitals and 112 penicillin-resistant (PRP) isolates (24%) were identified in 11 institutions. A case control study of 100 patients with penicillin-resistant and susceptible pneumococci from four of the widely dispersed hospitals revealed a high incidence of underlying medical illnesses in adult patients (74%), a preponderance of patients with pneumonia (63%), and a majority of patients who had underlying risk factors for pneumonia or invasive disease (51%). In this limited case control study, no difference was noted between cases and controls regarding known risk factors for penicillin-resistant pneumococcal infections. The percentage of single-patient PRP isolates varied among individual hospitals but the mean percentages of PRP from the four participating University Medical Centers and seven community hospitals were similar: 26% and 22% respectively. By E-test, 60% and 26% were high-level penicillin and ceftriaxone resistant, respectively. Pulsed-field gel electrophoresis identified 26 chromosomal macrorestriction patterns among the 103 PRP isolates available for analysis, but almost half (50 isolates or 48%) of these belong to two drug-resistant internationally spread clones, SP23-1 and Sp9/14-3, that were detected in all hospitals and were recovered from invasive and noninvasive sites in both children and adults.
AB - During the 4-month period from January to April, 1998, 476 patients with Streptococcus pneumoniae infections were detected in 12 metropolitan New York hospitals and 112 penicillin-resistant (PRP) isolates (24%) were identified in 11 institutions. A case control study of 100 patients with penicillin-resistant and susceptible pneumococci from four of the widely dispersed hospitals revealed a high incidence of underlying medical illnesses in adult patients (74%), a preponderance of patients with pneumonia (63%), and a majority of patients who had underlying risk factors for pneumonia or invasive disease (51%). In this limited case control study, no difference was noted between cases and controls regarding known risk factors for penicillin-resistant pneumococcal infections. The percentage of single-patient PRP isolates varied among individual hospitals but the mean percentages of PRP from the four participating University Medical Centers and seven community hospitals were similar: 26% and 22% respectively. By E-test, 60% and 26% were high-level penicillin and ceftriaxone resistant, respectively. Pulsed-field gel electrophoresis identified 26 chromosomal macrorestriction patterns among the 103 PRP isolates available for analysis, but almost half (50 isolates or 48%) of these belong to two drug-resistant internationally spread clones, SP23-1 and Sp9/14-3, that were detected in all hospitals and were recovered from invasive and noninvasive sites in both children and adults.
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U2 - 10.1089/10766290152045011
DO - 10.1089/10766290152045011
M3 - Article
C2 - 11442340
AN - SCOPUS:0034948838
SN - 1076-6294
VL - 7
SP - 137
EP - 152
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
IS - 2
ER -