Pediatric solid malignant neoplasms

A comparative analysis

Bryan E. Harmon, Kenneth Friedman, Barbara Nemesure, Meenakshi Singh

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Background: Pediatric solid malignant neoplasms (PSMNs) are a significant cause of death among children. Our aim was to evaluate the pattern and frequency of PSMNs at our hospital in the United States and compare the results to data from other regions of the world. Materials and Methods: This is a retrospective review of 127 PSMNs in the Pathology database at Stony Brook University Medical Center (SBUMC) from 2000 to 2008. We compared our cases to a cohort of 101 cases from an academic hospital in India (1975-1982) (Christian Medical College and Hospital) and to reports from other parts of the world. Results: We report a male to female ratio of 1.16: 1 and a mean age of 4.8 years for cases at SBUMC. Lymphomas and central nervous system (CNS) neoplasms were more common in the 5-12-year-old group while other major diagnostic groups were more common in the 0-4-year-old group. The top five most frequent tumor categories included CNS, sympathetic nervous system (SNS), soft tissue, lymphoid and renal tumors. Lymphomas were more common than soft tissue and SNS tumors in the United States' registries but all three occurred with equal frequency in our study. Tumors of the soft tissue and SNS were more frequent at SBUMC compared to registries around the world. At the academic hospital in India, the male to female ratio was 4: 1 and the five most frequent tumor categories included lymphoid, SNS, CNS, renal and bone tumors. Lymphoid tumors made up a greater percentage and CNS tumors made up a lesser percentage of tumors at the hospital in India compared with SBUMC. The differences between CNS tumors, lymphomas and retinoblastomas between the two hospitals were statistically significant (P value <0.05 by Fisher's Exact test). Conclusions: Geographic differences in the incidence and histologic types of PSMNs exist. Despite advancements in diagnosis and treatment, PSMNs continue to be tragically lethal.

Original languageEnglish (US)
Pages (from-to)514-519
Number of pages6
JournalIndian Journal of Pathology and Microbiology
Volume54
Issue number3
DOIs
StatePublished - Jul 2011
Externally publishedYes

Fingerprint

Pediatrics
Neoplasms
Sympathetic Nervous System
Central Nervous System Neoplasms
India
Lymphoma
Registries
Central Nervous System
Nervous System Neoplasms
Kidney
Retinoblastoma
Lymphoid Tissue
Cause of Death
Databases
Pathology
Bone and Bones
Incidence

Keywords

  • cancer
  • Childhood
  • malignant
  • pediatric
  • tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)

Cite this

Pediatric solid malignant neoplasms : A comparative analysis. / Harmon, Bryan E.; Friedman, Kenneth; Nemesure, Barbara; Singh, Meenakshi.

In: Indian Journal of Pathology and Microbiology, Vol. 54, No. 3, 07.2011, p. 514-519.

Research output: Contribution to journalReview article

Harmon, Bryan E. ; Friedman, Kenneth ; Nemesure, Barbara ; Singh, Meenakshi. / Pediatric solid malignant neoplasms : A comparative analysis. In: Indian Journal of Pathology and Microbiology. 2011 ; Vol. 54, No. 3. pp. 514-519.
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