TY - JOUR
T1 - Pediatric Soft Tissue Sarcomas
AU - Loeb, David M.
AU - Thornton, Katherine
AU - Shokek, Ori
PY - 2008/6
Y1 - 2008/6
N2 - Soft tissue sarcomas in children are rare. Approximately 850 to 900 children and adolescents are diagnosed each year with rhabdomyosarcoma (RMS) or a non-RMS soft tissue sarcoma (NRSTS). RMS is more common in children 14 years old and younger and NRSTS in adolescents and young adults. Infants get NRSTS, but their tumors constitute a distinctive set of histologies. Surgery is a major therapeutic modality and radiation plays a role. RMS is treated with adjuvant chemotherapy, whereas chemotherapy is reserved for the NRSTS that are high grade or unresectable. This review discusses the etiology, biology, and treatment of pediatric soft tissue sarcomas.
AB - Soft tissue sarcomas in children are rare. Approximately 850 to 900 children and adolescents are diagnosed each year with rhabdomyosarcoma (RMS) or a non-RMS soft tissue sarcoma (NRSTS). RMS is more common in children 14 years old and younger and NRSTS in adolescents and young adults. Infants get NRSTS, but their tumors constitute a distinctive set of histologies. Surgery is a major therapeutic modality and radiation plays a role. RMS is treated with adjuvant chemotherapy, whereas chemotherapy is reserved for the NRSTS that are high grade or unresectable. This review discusses the etiology, biology, and treatment of pediatric soft tissue sarcomas.
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U2 - 10.1016/j.suc.2008.03.008
DO - 10.1016/j.suc.2008.03.008
M3 - Review article
C2 - 18514702
AN - SCOPUS:44449105496
SN - 0039-6109
VL - 88
SP - 615
EP - 627
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 3
ER -