PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract

Guo Xia Tong, Lorenzo Memeo, Cristina Colarossi, Diane Hamele-Bena, Cristina Magi-Galluzzi, Ming Zhou, Stephen M. Lagana, Lara Harik, Jennifer M. Oliver-Krasinski, Mahesh Mansukhani, Lorenzo Falcone, Hanina Hibshoosh, Kathleen O'Toole

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

PAX8 and PAX2 are cell-lineage-specific transcription factors that are essential for the development of Wolffian and Müllerian ducts and have recently emerged as specific diagnostic markers for tumors of renal or Müllerian origin. Little is known about their expression in the Wolffian duct-derived human male genital tract. We report our findings of PAX8 and PAX2 expression in the epithelium of the normal male genital tract and in epithelial tumors derived therefrom using immunohistochemistry (IHC). We found that PAX8 and PAX2 were expressed in the epithelium of the male genital tract from the rete testis to the ejaculatory duct. Rare glands in the prostatic central zone, a tissue of purported Wolffian duct origin, were focally positive for PAX2, but no PAX8 was detected in this area, a finding that may warrant further study. We found diffuse expression of PAX8 and PAX2 in 1 case each of serous cystadenoma of the epididymis, carcinoma of the rete testis, Wolffian adnexal tumor of the seminal vesicle, and endometrioid carcinoma of the seminal vesicle. Neither PAX8 nor PAX2 was detected in the seminiferous tubules and interstitium of the normal testis, nor in Leydig cell tumors (n=6), Sertoli cell tumors (n=2), or 48 of 49 germ cell tumors. One pediatric yolk sac tumor showed focal and weak staining for PAX8. Tumors of mesothelial origin, that is, adenomatoid tumors (n=3) and peritoneal malignant mesotheliomas (n=37) in men, were negative for PAX2 and PAX8. Neither PAX2 nor PAX8 was present in other areas of the prostate. Expression of PAX8 and PAX2 in these primary epithelial neoplasms of the male genital tract is due to their histogenetic relationship with Wolffian or Müllerian ducts. PAX8 and PAX2 IHC may facilitate the diagnosis of these tumors and should be included in the differential diagnostic IHC panel.

Original languageEnglish (US)
Pages (from-to)1473-1483
Number of pages11
JournalAmerican Journal of Surgical Pathology
Volume35
Issue number10
DOIs
StatePublished - Oct 1 2011

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Glandular and Epithelial Neoplasms
Wolffian Ducts
Rete Testis
Seminal Vesicles
Immunohistochemistry
Epithelium
Sertoli Cell Tumor
Ejaculatory Ducts
Adenomatoid Tumor
Serous Cystadenoma
Leydig Cell Tumor
Endodermal Sinus Tumor
Endometrioid Carcinoma
Neoplasms
Seminiferous Tubules
Epididymis
Germ Cell and Embryonal Neoplasms
Cell Lineage
Tumor Biomarkers
Testis

Keywords

  • epithelial tumor
  • male genital tract
  • PAX8 and PAX2

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Tong, G. X., Memeo, L., Colarossi, C., Hamele-Bena, D., Magi-Galluzzi, C., Zhou, M., ... O'Toole, K. (2011). PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract. American Journal of Surgical Pathology, 35(10), 1473-1483. https://doi.org/10.1097/PAS.0b013e318227e2ee

PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract. / Tong, Guo Xia; Memeo, Lorenzo; Colarossi, Cristina; Hamele-Bena, Diane; Magi-Galluzzi, Cristina; Zhou, Ming; Lagana, Stephen M.; Harik, Lara; Oliver-Krasinski, Jennifer M.; Mansukhani, Mahesh; Falcone, Lorenzo; Hibshoosh, Hanina; O'Toole, Kathleen.

In: American Journal of Surgical Pathology, Vol. 35, No. 10, 01.10.2011, p. 1473-1483.

Research output: Contribution to journalArticle

Tong, GX, Memeo, L, Colarossi, C, Hamele-Bena, D, Magi-Galluzzi, C, Zhou, M, Lagana, SM, Harik, L, Oliver-Krasinski, JM, Mansukhani, M, Falcone, L, Hibshoosh, H & O'Toole, K 2011, 'PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract', American Journal of Surgical Pathology, vol. 35, no. 10, pp. 1473-1483. https://doi.org/10.1097/PAS.0b013e318227e2ee
Tong, Guo Xia ; Memeo, Lorenzo ; Colarossi, Cristina ; Hamele-Bena, Diane ; Magi-Galluzzi, Cristina ; Zhou, Ming ; Lagana, Stephen M. ; Harik, Lara ; Oliver-Krasinski, Jennifer M. ; Mansukhani, Mahesh ; Falcone, Lorenzo ; Hibshoosh, Hanina ; O'Toole, Kathleen. / PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract. In: American Journal of Surgical Pathology. 2011 ; Vol. 35, No. 10. pp. 1473-1483.
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AU - Magi-Galluzzi, Cristina

AU - Zhou, Ming

AU - Lagana, Stephen M.

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AU - Oliver-Krasinski, Jennifer M.

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