Pathophysiologic effects of bowel distention on intestinal blood flow

Scott J. Boley, Girdhar P. Agrawal, Allan R. Warren, Frank J. Veith, Bernard S. Levowitz, William Treiber, Joseph Dougherty, Solomon S. Schwartz, Marvin L. Gliedman

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

1. 1. The effects of acute bowel distention on intestinal circulation were studied in dogs. 2. 2. Intraluminal pressures at or above 30 mm. Hg produced a consistent immediate fall in intestinal blood flow. Higher pressures produced correspondingly greater diminutions in flow until an irreducible 20 to 35 per cent of flow remained. 3. 3. As blood flow fell, there was an associated decrease in the arteriovenous oxygen difference indicating diminished oxygen extraction by the intestine. 4. 4. Injection studies performed in situ with increasing intraluminal pressures showed filling of only the submucosal and serosal vessels with pressures at or above 60 to 90 mm. Hg. 5. 5. Krypton 85 washout studies are compatible with a shift of blood flow away from the mucosa at intraluminal pressures above 60 mm. Hg. 6. 6. These findings indicate that above an intraluminal pressure of 30 mm. Hg, blood is shunted through functional or anatomic arteriovenous communications depriving the bowel mucosa. 7. 7. The roles of increased intraluminal pressure, intestinal ischemia, and hypoxia are discussed as accounting for the colitis seen proximal to colonic neoplasms.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalThe American Journal of Surgery
Volume117
Issue number2
StatePublished - Feb 1969
Externally publishedYes

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Pressure
Mucous Membrane
Krypton
Oxygen
Colitis
Colonic Neoplasms
Intestines
Ischemia
Communication
Dogs
Injections

ASJC Scopus subject areas

  • Surgery

Cite this

Boley, S. J., Agrawal, G. P., Warren, A. R., Veith, F. J., Levowitz, B. S., Treiber, W., ... Gliedman, M. L. (1969). Pathophysiologic effects of bowel distention on intestinal blood flow. The American Journal of Surgery, 117(2), 228-234.

Pathophysiologic effects of bowel distention on intestinal blood flow. / Boley, Scott J.; Agrawal, Girdhar P.; Warren, Allan R.; Veith, Frank J.; Levowitz, Bernard S.; Treiber, William; Dougherty, Joseph; Schwartz, Solomon S.; Gliedman, Marvin L.

In: The American Journal of Surgery, Vol. 117, No. 2, 02.1969, p. 228-234.

Research output: Contribution to journalArticle

Boley, SJ, Agrawal, GP, Warren, AR, Veith, FJ, Levowitz, BS, Treiber, W, Dougherty, J, Schwartz, SS & Gliedman, ML 1969, 'Pathophysiologic effects of bowel distention on intestinal blood flow', The American Journal of Surgery, vol. 117, no. 2, pp. 228-234.
Boley SJ, Agrawal GP, Warren AR, Veith FJ, Levowitz BS, Treiber W et al. Pathophysiologic effects of bowel distention on intestinal blood flow. The American Journal of Surgery. 1969 Feb;117(2):228-234.
Boley, Scott J. ; Agrawal, Girdhar P. ; Warren, Allan R. ; Veith, Frank J. ; Levowitz, Bernard S. ; Treiber, William ; Dougherty, Joseph ; Schwartz, Solomon S. ; Gliedman, Marvin L. / Pathophysiologic effects of bowel distention on intestinal blood flow. In: The American Journal of Surgery. 1969 ; Vol. 117, No. 2. pp. 228-234.
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