Pathological Stage T3a Significantly Increases Disease Recurrence across All Tumor Sizes in Renal Cell Carcinoma

Michael Chevinsky, Mariam Imnadze, Alexander I. Sankin, Andrew Winer, Roy Mano, Christopher Jakubowski, Joseph Mashni, Daniel D. Sjoberg, Ying Bei Chen, Satish K. Tickoo, Victor E. Reuter, A. Ari Hakimi, Paul Russo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose Tumor size and stage are important prognostic parameters in renal cell carcinoma. While pathological stage T1 and T2 are defined by size alone, the presence of certain intrinsic features can up stage a tumor to pathological stage T3a regardless of size. We investigate the effect of pathological tumor stage on the relationship between tumor size and risk of disease recurrence. Materials and Methods Data were reviewed on patients who underwent nephrectomy at our institution between 2006 and 2013 to identify all those with pathological stage T1, T2 and T3a tumors. A proportional hazards Cox model was built with time to recurrence as outcome, and pathological stage and tumor size as covariates. An interaction term for stage and tumor size was included. Results The final cohort included 1,809 patients. On multivariable analysis, when adjusted for tumor size, patients with pT3a tumors had a greater risk of tumor recurrence compared to those with pT1/T2 tumors (HR 3.70; 95% CI 2.31, 5.92; p

Original languageEnglish (US)
Pages (from-to)310-315
Number of pages6
JournalJournal of Urology
Volume194
Issue number2
DOIs
StatePublished - 2015
Externally publishedYes

Fingerprint

Renal Cell Carcinoma
Recurrence
Neoplasms
Nephrectomy
Proportional Hazards Models

Keywords

  • carcinoma
  • neoplasm staging
  • recurrence
  • renal cell

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Pathological Stage T3a Significantly Increases Disease Recurrence across All Tumor Sizes in Renal Cell Carcinoma. / Chevinsky, Michael; Imnadze, Mariam; Sankin, Alexander I.; Winer, Andrew; Mano, Roy; Jakubowski, Christopher; Mashni, Joseph; Sjoberg, Daniel D.; Chen, Ying Bei; Tickoo, Satish K.; Reuter, Victor E.; Hakimi, A. Ari; Russo, Paul.

In: Journal of Urology, Vol. 194, No. 2, 2015, p. 310-315.

Research output: Contribution to journalArticle

Chevinsky, M, Imnadze, M, Sankin, AI, Winer, A, Mano, R, Jakubowski, C, Mashni, J, Sjoberg, DD, Chen, YB, Tickoo, SK, Reuter, VE, Hakimi, AA & Russo, P 2015, 'Pathological Stage T3a Significantly Increases Disease Recurrence across All Tumor Sizes in Renal Cell Carcinoma', Journal of Urology, vol. 194, no. 2, pp. 310-315. https://doi.org/10.1016/j.juro.2015.02.013
Chevinsky, Michael ; Imnadze, Mariam ; Sankin, Alexander I. ; Winer, Andrew ; Mano, Roy ; Jakubowski, Christopher ; Mashni, Joseph ; Sjoberg, Daniel D. ; Chen, Ying Bei ; Tickoo, Satish K. ; Reuter, Victor E. ; Hakimi, A. Ari ; Russo, Paul. / Pathological Stage T3a Significantly Increases Disease Recurrence across All Tumor Sizes in Renal Cell Carcinoma. In: Journal of Urology. 2015 ; Vol. 194, No. 2. pp. 310-315.
@article{88a4becf4b054bd3b7f40d7933b7a59b,
title = "Pathological Stage T3a Significantly Increases Disease Recurrence across All Tumor Sizes in Renal Cell Carcinoma",
abstract = "Purpose Tumor size and stage are important prognostic parameters in renal cell carcinoma. While pathological stage T1 and T2 are defined by size alone, the presence of certain intrinsic features can up stage a tumor to pathological stage T3a regardless of size. We investigate the effect of pathological tumor stage on the relationship between tumor size and risk of disease recurrence. Materials and Methods Data were reviewed on patients who underwent nephrectomy at our institution between 2006 and 2013 to identify all those with pathological stage T1, T2 and T3a tumors. A proportional hazards Cox model was built with time to recurrence as outcome, and pathological stage and tumor size as covariates. An interaction term for stage and tumor size was included. Results The final cohort included 1,809 patients. On multivariable analysis, when adjusted for tumor size, patients with pT3a tumors had a greater risk of tumor recurrence compared to those with pT1/T2 tumors (HR 3.70; 95{\%} CI 2.31, 5.92; p",
keywords = "carcinoma, neoplasm staging, recurrence, renal cell",
author = "Michael Chevinsky and Mariam Imnadze and Sankin, {Alexander I.} and Andrew Winer and Roy Mano and Christopher Jakubowski and Joseph Mashni and Sjoberg, {Daniel D.} and Chen, {Ying Bei} and Tickoo, {Satish K.} and Reuter, {Victor E.} and Hakimi, {A. Ari} and Paul Russo",
year = "2015",
doi = "10.1016/j.juro.2015.02.013",
language = "English (US)",
volume = "194",
pages = "310--315",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Pathological Stage T3a Significantly Increases Disease Recurrence across All Tumor Sizes in Renal Cell Carcinoma

AU - Chevinsky, Michael

AU - Imnadze, Mariam

AU - Sankin, Alexander I.

AU - Winer, Andrew

AU - Mano, Roy

AU - Jakubowski, Christopher

AU - Mashni, Joseph

AU - Sjoberg, Daniel D.

AU - Chen, Ying Bei

AU - Tickoo, Satish K.

AU - Reuter, Victor E.

AU - Hakimi, A. Ari

AU - Russo, Paul

PY - 2015

Y1 - 2015

N2 - Purpose Tumor size and stage are important prognostic parameters in renal cell carcinoma. While pathological stage T1 and T2 are defined by size alone, the presence of certain intrinsic features can up stage a tumor to pathological stage T3a regardless of size. We investigate the effect of pathological tumor stage on the relationship between tumor size and risk of disease recurrence. Materials and Methods Data were reviewed on patients who underwent nephrectomy at our institution between 2006 and 2013 to identify all those with pathological stage T1, T2 and T3a tumors. A proportional hazards Cox model was built with time to recurrence as outcome, and pathological stage and tumor size as covariates. An interaction term for stage and tumor size was included. Results The final cohort included 1,809 patients. On multivariable analysis, when adjusted for tumor size, patients with pT3a tumors had a greater risk of tumor recurrence compared to those with pT1/T2 tumors (HR 3.70; 95% CI 2.31, 5.92; p

AB - Purpose Tumor size and stage are important prognostic parameters in renal cell carcinoma. While pathological stage T1 and T2 are defined by size alone, the presence of certain intrinsic features can up stage a tumor to pathological stage T3a regardless of size. We investigate the effect of pathological tumor stage on the relationship between tumor size and risk of disease recurrence. Materials and Methods Data were reviewed on patients who underwent nephrectomy at our institution between 2006 and 2013 to identify all those with pathological stage T1, T2 and T3a tumors. A proportional hazards Cox model was built with time to recurrence as outcome, and pathological stage and tumor size as covariates. An interaction term for stage and tumor size was included. Results The final cohort included 1,809 patients. On multivariable analysis, when adjusted for tumor size, patients with pT3a tumors had a greater risk of tumor recurrence compared to those with pT1/T2 tumors (HR 3.70; 95% CI 2.31, 5.92; p

KW - carcinoma

KW - neoplasm staging

KW - recurrence

KW - renal cell

UR - http://www.scopus.com/inward/record.url?scp=84952629965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952629965&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2015.02.013

DO - 10.1016/j.juro.2015.02.013

M3 - Article

C2 - 25676433

AN - SCOPUS:84952629965

VL - 194

SP - 310

EP - 315

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -