Pathologic predictors of recurrence in stage 1 (TINOMO) breast cancer

D. F. Roses, D. A. Bell, T. J. Flotte, R. Taylor, H. Ratech, N. Dubin

Research output: Contribution to journalArticle

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Abstract

A group of 122 consecutively treated pathologic Stage 1 (TINOMO) patients with cancer of the breast were studied to define histopathologic predictors of recurrence. Lymphatic invasion was the most significant predictor of recurrence; recurrence was present in 32% (8/25) of patients who had lymphatic invasion and in 10.3% (10/97) of patients who did not (P = 0.006). Histologic type was also predictive of recurrent disease. Eighteen per cent (18/101) of patients with invasive ductal or lobular carcinoma developed recurrent disease, while none of the group of 21 patients with medullary carcinoma, tubular carcinoma, colloid carcinoma, Paget's disease, and intraductal carcinoma with minimal invasion suffered a recurrence (P = 0.036). Vascular invasion, grade of malignancy, cellularity, presence or absence of circumscription, cellular infiltrate, fibroblastic response, neural invasion, and necrosis were not significant predictors of recurrence. Multiple logistic regression analysis of patients with invasive ductal or lobular carcinoma confirmed the results for individual factors, that only patients with lymphatic invasion were at higher risk of recurrence.

Original languageEnglish (US)
Pages (from-to)817-820
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume78
Issue number6
StatePublished - 1982
Externally publishedYes

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Breast Neoplasms
Recurrence
Lobular Carcinoma
Ductal Carcinoma
Mucinous Adenocarcinoma
Medullary Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Blood Vessels
Adenocarcinoma
Necrosis
Logistic Models
Regression Analysis
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Roses, D. F., Bell, D. A., Flotte, T. J., Taylor, R., Ratech, H., & Dubin, N. (1982). Pathologic predictors of recurrence in stage 1 (TINOMO) breast cancer. American Journal of Clinical Pathology, 78(6), 817-820.

Pathologic predictors of recurrence in stage 1 (TINOMO) breast cancer. / Roses, D. F.; Bell, D. A.; Flotte, T. J.; Taylor, R.; Ratech, H.; Dubin, N.

In: American Journal of Clinical Pathology, Vol. 78, No. 6, 1982, p. 817-820.

Research output: Contribution to journalArticle

Roses, DF, Bell, DA, Flotte, TJ, Taylor, R, Ratech, H & Dubin, N 1982, 'Pathologic predictors of recurrence in stage 1 (TINOMO) breast cancer', American Journal of Clinical Pathology, vol. 78, no. 6, pp. 817-820.
Roses DF, Bell DA, Flotte TJ, Taylor R, Ratech H, Dubin N. Pathologic predictors of recurrence in stage 1 (TINOMO) breast cancer. American Journal of Clinical Pathology. 1982;78(6):817-820.
Roses, D. F. ; Bell, D. A. ; Flotte, T. J. ; Taylor, R. ; Ratech, H. ; Dubin, N. / Pathologic predictors of recurrence in stage 1 (TINOMO) breast cancer. In: American Journal of Clinical Pathology. 1982 ; Vol. 78, No. 6. pp. 817-820.
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