Pathogenesis of Microvascular Complications

Ferdinando Giacco, Michael Brownlee

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)
Original languageEnglish (US)
Title of host publicationTextbook of Diabetes: Fourth Edition
PublisherWiley-Blackwell
Pages553-574
Number of pages22
ISBN (Print)9781405191814
DOIs
StatePublished - Jul 9 2010

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Vascular Endothelial Growth Factor A
NAADP

Keywords

  • A single process underlying different hyperglycemia-induced pathogenic mechanisms: mitochondrial superoxide production
  • Determinants of individual susceptibility to hyperglycemia-induced damage
  • Hyperglycemia-induced mitochondrial superoxide production activates the five damaging pathways by inhibiting GAPDH
  • Hyperglycemia-induced mitochondrial superoxide production inhibits GAPDH by activating poly(ADP-ribose) polymerase
  • Mechanisms of hyperglycemia-induced damage
  • Nicotinic acid adenine dinucleotide phosphate (NADPH)
  • Potential mechanism-based therapeutic agents for diabetic complications
  • Receptor-mediated biologic effects of AGEs
  • Role of hyperglycemia in microvascular complications
  • Vascular endothelial growth factor (VEGF)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Giacco, F., & Brownlee, M. (2010). Pathogenesis of Microvascular Complications. In Textbook of Diabetes: Fourth Edition (pp. 553-574). Wiley-Blackwell. https://doi.org/10.1002/9781444324808.ch35

Pathogenesis of Microvascular Complications. / Giacco, Ferdinando; Brownlee, Michael.

Textbook of Diabetes: Fourth Edition. Wiley-Blackwell, 2010. p. 553-574.

Research output: Chapter in Book/Report/Conference proceedingChapter

Giacco, F & Brownlee, M 2010, Pathogenesis of Microvascular Complications. in Textbook of Diabetes: Fourth Edition. Wiley-Blackwell, pp. 553-574. https://doi.org/10.1002/9781444324808.ch35
Giacco F, Brownlee M. Pathogenesis of Microvascular Complications. In Textbook of Diabetes: Fourth Edition. Wiley-Blackwell. 2010. p. 553-574 https://doi.org/10.1002/9781444324808.ch35
Giacco, Ferdinando ; Brownlee, Michael. / Pathogenesis of Microvascular Complications. Textbook of Diabetes: Fourth Edition. Wiley-Blackwell, 2010. pp. 553-574
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