Pathogenesis of Microvascular Complications

Ferdinando Giacco, Michael Brownlee

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations
Original languageEnglish (US)
Title of host publicationTextbook of Diabetes
Subtitle of host publicationFourth Edition
Number of pages22
ISBN (Print)9781405191814
Publication statusPublished - Jul 9 2010


  • A single process underlying different hyperglycemia-induced pathogenic mechanisms: mitochondrial superoxide production
  • Determinants of individual susceptibility to hyperglycemia-induced damage
  • Hyperglycemia-induced mitochondrial superoxide production activates the five damaging pathways by inhibiting GAPDH
  • Hyperglycemia-induced mitochondrial superoxide production inhibits GAPDH by activating poly(ADP-ribose) polymerase
  • Mechanisms of hyperglycemia-induced damage
  • Nicotinic acid adenine dinucleotide phosphate (NADPH)
  • Potential mechanism-based therapeutic agents for diabetic complications
  • Receptor-mediated biologic effects of AGEs
  • Role of hyperglycemia in microvascular complications
  • Vascular endothelial growth factor (VEGF)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Giacco, F., & Brownlee, M. (2010). Pathogenesis of Microvascular Complications. In Textbook of Diabetes: Fourth Edition (pp. 553-574). Wiley-Blackwell.