Pathogenesis and therapy of psoriasis

Michelle A. Lowes, Anne M. Bowcock, James G. Krueger

Research output: Contribution to journalReview article

1192 Scopus citations

Abstract

Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.

Original languageEnglish (US)
Pages (from-to)866-873
Number of pages8
JournalNature
Volume445
Issue number7130
DOIs
StatePublished - Feb 22 2007

ASJC Scopus subject areas

  • General

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    Lowes, M. A., Bowcock, A. M., & Krueger, J. G. (2007). Pathogenesis and therapy of psoriasis. Nature, 445(7130), 866-873. https://doi.org/10.1038/nature05663