Pathogenesis and therapy of psoriasis

Michelle A. Lowes, Anne M. Bowcock, James G. Krueger

Research output: Contribution to journalArticle

1144 Citations (Scopus)

Abstract

Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.

Original languageEnglish (US)
Pages (from-to)866-873
Number of pages8
JournalNature
Volume445
Issue number7130
DOIs
StatePublished - Feb 22 2007
Externally publishedYes

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Keratinocytes
Psoriasis
Chemokines
Skin Diseases
Dendritic Cells
Immune System
Cytokines
T-Lymphocytes
Therapeutics
Growth

ASJC Scopus subject areas

  • General

Cite this

Lowes, M. A., Bowcock, A. M., & Krueger, J. G. (2007). Pathogenesis and therapy of psoriasis. Nature, 445(7130), 866-873. https://doi.org/10.1038/nature05663

Pathogenesis and therapy of psoriasis. / Lowes, Michelle A.; Bowcock, Anne M.; Krueger, James G.

In: Nature, Vol. 445, No. 7130, 22.02.2007, p. 866-873.

Research output: Contribution to journalArticle

Lowes, MA, Bowcock, AM & Krueger, JG 2007, 'Pathogenesis and therapy of psoriasis', Nature, vol. 445, no. 7130, pp. 866-873. https://doi.org/10.1038/nature05663
Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature. 2007 Feb 22;445(7130):866-873. https://doi.org/10.1038/nature05663
Lowes, Michelle A. ; Bowcock, Anne M. ; Krueger, James G. / Pathogenesis and therapy of psoriasis. In: Nature. 2007 ; Vol. 445, No. 7130. pp. 866-873.
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