Pathogenesis and therapy of psoriasis

Michelle A. Lowes; Anne M. Bowcock; James G. Krueger

doi:10.1038/nature05663

Pathogenesis and therapy of psoriasis

Michelle A. Lowes, Anne M. Bowcock, James G. Krueger

Research output: Contribution to journal › Review article › peer-review

1500 Scopus citations

Abstract

Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.

Original language	English (US)
Pages (from-to)	866-873
Number of pages	8
Journal	Nature
Volume	445
Issue number	7130
DOIs	https://doi.org/10.1038/nature05663
State	Published - Feb 22 2007
Externally published	Yes

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nature05663

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title = "Pathogenesis and therapy of psoriasis",

abstract = "Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.",

author = "Lowes, {Michelle A.} and Bowcock, {Anne M.} and Krueger, {James G.}",

note = "Funding Information: Acknowledgements The authors and their primary research have been supported by grants from the NIH.",

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AU - Lowes, Michelle A.

AU - Bowcock, Anne M.

AU - Krueger, James G.

N1 - Funding Information: Acknowledgements The authors and their primary research have been supported by grants from the NIH.

PY - 2007/2/22

Y1 - 2007/2/22

N2 - Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.

AB - Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.

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JO - Nature

JF - Nature

IS - 7130

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Pathogenesis and therapy of psoriasis

Abstract

ASJC Scopus subject areas

UN SDGs

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