Parvocellular and magnocellular contributions to the initial generators of the visual evoked potential

High-density electrical mapping of the "C1" component

John J. Foxe, E. Cathrine Strugstad, Pejman Sehatpour, Sophie Molholm, Wren Pasieka, Charles E. Schroeder, Mark E. McCourt

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The C1 component of the VEP is considered to index initial afference of retinotopic regions of human visual cortex (V1 and V2). C1 onsets over central parieto-occipital scalp between 45 and 60 ms, peaks between 70 and 100 ms, and then resolves into the following P1 component. By exploiting isoluminant and low-contrast luminance stimuli, we assessed the relative contributions of the Magnocellular (M) and Parvocellular (P) pathways to generation of C1. C1 was maximal at 88 ms in a 100% luminance contrast condition (which stimulates both P and M pathways) and at 115 ms in an isoluminant chromatic condition (which isolates contributions of the P pathway). However, in a 4% luminance contrast condition (which isolates the M pathway), where the stimuli were still clearly perceived, C1 was completely absent. Absence of C1 in this low contrast condition is unlikely to be attributable to lack of stimulus energy since a robust P1-N1 complex was evoked. These data therefore imply that C1 may be primarily parvocellular in origin. The data do not, however, rule out some contribution from the M system at higher contrast levels. Nonetheless, that the amplitude of C1 to P-isolating isoluminant chromatic stimuli is equivalent to that evoked by 100% contrast stimuli suggests that even at high contrast levels, the P system is the largest contributor. These data are related to intracranial recordings in macaque monkeys that have also suggested that the initial current sink in layer IV may not propagate effectively to the scalp surface when M-biased stimuli are used. We also discuss how this finding has implications for a long tradition of attention research that has used C1 as a metric of initial V1 afference in humans. C1 has been repeatedly interrogated for potential selective attentional modulations, particularly in spatial attentional designs, under the premise that modulation of this component, or lack thereof, would be evidence for or against selection at the initial inputs to visual cortex. Given the findings here, we would urge that in interpreting C1 effects, a consideration of the dominant cellular contributions will be necessary. For example, it is plausible that spatial attention mechanisms could operate primarily through the M system and that as such C1 may not always represent an adequate dependent measure in such studies.

Original languageEnglish (US)
Pages (from-to)11-21
Number of pages11
JournalBrain Topography
Volume21
Issue number1
DOIs
StatePublished - Sep 2008
Externally publishedYes

Fingerprint

Visual Evoked Potentials
Visual Cortex
Scalp
Color
Macaca
Haplorhini
Research

Keywords

  • C1 component
  • Contrast-sensitivity
  • Event-related potential (ERP)
  • Magnocellular
  • Parvocellular
  • Spatial attention
  • Striate cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Parvocellular and magnocellular contributions to the initial generators of the visual evoked potential : High-density electrical mapping of the "C1" component. / Foxe, John J.; Strugstad, E. Cathrine; Sehatpour, Pejman; Molholm, Sophie; Pasieka, Wren; Schroeder, Charles E.; McCourt, Mark E.

In: Brain Topography, Vol. 21, No. 1, 09.2008, p. 11-21.

Research output: Contribution to journalArticle

Foxe, John J. ; Strugstad, E. Cathrine ; Sehatpour, Pejman ; Molholm, Sophie ; Pasieka, Wren ; Schroeder, Charles E. ; McCourt, Mark E. / Parvocellular and magnocellular contributions to the initial generators of the visual evoked potential : High-density electrical mapping of the "C1" component. In: Brain Topography. 2008 ; Vol. 21, No. 1. pp. 11-21.
@article{e263394f472a4093bcd3a8875f562684,
title = "Parvocellular and magnocellular contributions to the initial generators of the visual evoked potential: High-density electrical mapping of the {"}C1{"} component",
abstract = "The C1 component of the VEP is considered to index initial afference of retinotopic regions of human visual cortex (V1 and V2). C1 onsets over central parieto-occipital scalp between 45 and 60 ms, peaks between 70 and 100 ms, and then resolves into the following P1 component. By exploiting isoluminant and low-contrast luminance stimuli, we assessed the relative contributions of the Magnocellular (M) and Parvocellular (P) pathways to generation of C1. C1 was maximal at 88 ms in a 100{\%} luminance contrast condition (which stimulates both P and M pathways) and at 115 ms in an isoluminant chromatic condition (which isolates contributions of the P pathway). However, in a 4{\%} luminance contrast condition (which isolates the M pathway), where the stimuli were still clearly perceived, C1 was completely absent. Absence of C1 in this low contrast condition is unlikely to be attributable to lack of stimulus energy since a robust P1-N1 complex was evoked. These data therefore imply that C1 may be primarily parvocellular in origin. The data do not, however, rule out some contribution from the M system at higher contrast levels. Nonetheless, that the amplitude of C1 to P-isolating isoluminant chromatic stimuli is equivalent to that evoked by 100{\%} contrast stimuli suggests that even at high contrast levels, the P system is the largest contributor. These data are related to intracranial recordings in macaque monkeys that have also suggested that the initial current sink in layer IV may not propagate effectively to the scalp surface when M-biased stimuli are used. We also discuss how this finding has implications for a long tradition of attention research that has used C1 as a metric of initial V1 afference in humans. C1 has been repeatedly interrogated for potential selective attentional modulations, particularly in spatial attentional designs, under the premise that modulation of this component, or lack thereof, would be evidence for or against selection at the initial inputs to visual cortex. Given the findings here, we would urge that in interpreting C1 effects, a consideration of the dominant cellular contributions will be necessary. For example, it is plausible that spatial attention mechanisms could operate primarily through the M system and that as such C1 may not always represent an adequate dependent measure in such studies.",
keywords = "C1 component, Contrast-sensitivity, Event-related potential (ERP), Magnocellular, Parvocellular, Spatial attention, Striate cortex",
author = "Foxe, {John J.} and Strugstad, {E. Cathrine} and Pejman Sehatpour and Sophie Molholm and Wren Pasieka and Schroeder, {Charles E.} and McCourt, {Mark E.}",
year = "2008",
month = "9",
doi = "10.1007/s10548-008-0063-4",
language = "English (US)",
volume = "21",
pages = "11--21",
journal = "Brain Topography",
issn = "0896-0267",
publisher = "Kluwer Academic/Human Sciences Press Inc.",
number = "1",

}

TY - JOUR

T1 - Parvocellular and magnocellular contributions to the initial generators of the visual evoked potential

T2 - High-density electrical mapping of the "C1" component

AU - Foxe, John J.

AU - Strugstad, E. Cathrine

AU - Sehatpour, Pejman

AU - Molholm, Sophie

AU - Pasieka, Wren

AU - Schroeder, Charles E.

AU - McCourt, Mark E.

PY - 2008/9

Y1 - 2008/9

N2 - The C1 component of the VEP is considered to index initial afference of retinotopic regions of human visual cortex (V1 and V2). C1 onsets over central parieto-occipital scalp between 45 and 60 ms, peaks between 70 and 100 ms, and then resolves into the following P1 component. By exploiting isoluminant and low-contrast luminance stimuli, we assessed the relative contributions of the Magnocellular (M) and Parvocellular (P) pathways to generation of C1. C1 was maximal at 88 ms in a 100% luminance contrast condition (which stimulates both P and M pathways) and at 115 ms in an isoluminant chromatic condition (which isolates contributions of the P pathway). However, in a 4% luminance contrast condition (which isolates the M pathway), where the stimuli were still clearly perceived, C1 was completely absent. Absence of C1 in this low contrast condition is unlikely to be attributable to lack of stimulus energy since a robust P1-N1 complex was evoked. These data therefore imply that C1 may be primarily parvocellular in origin. The data do not, however, rule out some contribution from the M system at higher contrast levels. Nonetheless, that the amplitude of C1 to P-isolating isoluminant chromatic stimuli is equivalent to that evoked by 100% contrast stimuli suggests that even at high contrast levels, the P system is the largest contributor. These data are related to intracranial recordings in macaque monkeys that have also suggested that the initial current sink in layer IV may not propagate effectively to the scalp surface when M-biased stimuli are used. We also discuss how this finding has implications for a long tradition of attention research that has used C1 as a metric of initial V1 afference in humans. C1 has been repeatedly interrogated for potential selective attentional modulations, particularly in spatial attentional designs, under the premise that modulation of this component, or lack thereof, would be evidence for or against selection at the initial inputs to visual cortex. Given the findings here, we would urge that in interpreting C1 effects, a consideration of the dominant cellular contributions will be necessary. For example, it is plausible that spatial attention mechanisms could operate primarily through the M system and that as such C1 may not always represent an adequate dependent measure in such studies.

AB - The C1 component of the VEP is considered to index initial afference of retinotopic regions of human visual cortex (V1 and V2). C1 onsets over central parieto-occipital scalp between 45 and 60 ms, peaks between 70 and 100 ms, and then resolves into the following P1 component. By exploiting isoluminant and low-contrast luminance stimuli, we assessed the relative contributions of the Magnocellular (M) and Parvocellular (P) pathways to generation of C1. C1 was maximal at 88 ms in a 100% luminance contrast condition (which stimulates both P and M pathways) and at 115 ms in an isoluminant chromatic condition (which isolates contributions of the P pathway). However, in a 4% luminance contrast condition (which isolates the M pathway), where the stimuli were still clearly perceived, C1 was completely absent. Absence of C1 in this low contrast condition is unlikely to be attributable to lack of stimulus energy since a robust P1-N1 complex was evoked. These data therefore imply that C1 may be primarily parvocellular in origin. The data do not, however, rule out some contribution from the M system at higher contrast levels. Nonetheless, that the amplitude of C1 to P-isolating isoluminant chromatic stimuli is equivalent to that evoked by 100% contrast stimuli suggests that even at high contrast levels, the P system is the largest contributor. These data are related to intracranial recordings in macaque monkeys that have also suggested that the initial current sink in layer IV may not propagate effectively to the scalp surface when M-biased stimuli are used. We also discuss how this finding has implications for a long tradition of attention research that has used C1 as a metric of initial V1 afference in humans. C1 has been repeatedly interrogated for potential selective attentional modulations, particularly in spatial attentional designs, under the premise that modulation of this component, or lack thereof, would be evidence for or against selection at the initial inputs to visual cortex. Given the findings here, we would urge that in interpreting C1 effects, a consideration of the dominant cellular contributions will be necessary. For example, it is plausible that spatial attention mechanisms could operate primarily through the M system and that as such C1 may not always represent an adequate dependent measure in such studies.

KW - C1 component

KW - Contrast-sensitivity

KW - Event-related potential (ERP)

KW - Magnocellular

KW - Parvocellular

KW - Spatial attention

KW - Striate cortex

UR - http://www.scopus.com/inward/record.url?scp=52549119907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52549119907&partnerID=8YFLogxK

U2 - 10.1007/s10548-008-0063-4

DO - 10.1007/s10548-008-0063-4

M3 - Article

VL - 21

SP - 11

EP - 21

JO - Brain Topography

JF - Brain Topography

SN - 0896-0267

IS - 1

ER -