Partial immunologic reconstitution of a patient with acquired agammaglobulinemia

A transient phenomenon accompanying therapeutic plasmapheresis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A patient with acquired agammaglobulinemia was treated with plasmapheresis. The rationale for this procedure was based on the presence of a cytotoxic autoantibody with specificity for helper (TH2-) T lymphocytes. Plasmapheresis reduced the autoantibody concentration to undetectable levels, which resulted in an increased number of helper T cells. These T cells provided normal in vitro helper activity. Plasmapheresis did not correct a concomitant suppressor T-cell defect, and the clinical remission ended during the fifth month of exchange therapy.

Original languageEnglish (US)
Pages (from-to)233-235
Number of pages3
JournalBlood
Volume59
Issue number2
StatePublished - 1982

Fingerprint

Agammaglobulinemia
Plasmapheresis
T-cells
Helper-Inducer T-Lymphocytes
Autoantibodies
T-Lymphocytes
Therapeutics
Defects

ASJC Scopus subject areas

  • Hematology

Cite this

@article{dbe8899284de4a0c8563a65831d89ef3,
title = "Partial immunologic reconstitution of a patient with acquired agammaglobulinemia: A transient phenomenon accompanying therapeutic plasmapheresis",
abstract = "A patient with acquired agammaglobulinemia was treated with plasmapheresis. The rationale for this procedure was based on the presence of a cytotoxic autoantibody with specificity for helper (TH2-) T lymphocytes. Plasmapheresis reduced the autoantibody concentration to undetectable levels, which resulted in an increased number of helper T cells. These T cells provided normal in vitro helper activity. Plasmapheresis did not correct a concomitant suppressor T-cell defect, and the clinical remission ended during the fifth month of exchange therapy.",
author = "B. Wenz and Arye Rubinstein",
year = "1982",
language = "English (US)",
volume = "59",
pages = "233--235",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "2",

}

TY - JOUR

T1 - Partial immunologic reconstitution of a patient with acquired agammaglobulinemia

T2 - A transient phenomenon accompanying therapeutic plasmapheresis

AU - Wenz, B.

AU - Rubinstein, Arye

PY - 1982

Y1 - 1982

N2 - A patient with acquired agammaglobulinemia was treated with plasmapheresis. The rationale for this procedure was based on the presence of a cytotoxic autoantibody with specificity for helper (TH2-) T lymphocytes. Plasmapheresis reduced the autoantibody concentration to undetectable levels, which resulted in an increased number of helper T cells. These T cells provided normal in vitro helper activity. Plasmapheresis did not correct a concomitant suppressor T-cell defect, and the clinical remission ended during the fifth month of exchange therapy.

AB - A patient with acquired agammaglobulinemia was treated with plasmapheresis. The rationale for this procedure was based on the presence of a cytotoxic autoantibody with specificity for helper (TH2-) T lymphocytes. Plasmapheresis reduced the autoantibody concentration to undetectable levels, which resulted in an increased number of helper T cells. These T cells provided normal in vitro helper activity. Plasmapheresis did not correct a concomitant suppressor T-cell defect, and the clinical remission ended during the fifth month of exchange therapy.

UR - http://www.scopus.com/inward/record.url?scp=0020030115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020030115&partnerID=8YFLogxK

M3 - Article

VL - 59

SP - 233

EP - 235

JO - Blood

JF - Blood

SN - 0006-4971

IS - 2

ER -