Partial immunologic reconstitution of a patient with acquired agammaglobulinemia: A transient phenomenon accompanying therapeutic plasmapheresis

B. Wenz, A. Rubinstein

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A patient with acquired agammaglobulinemia was treated with plasmapheresis. The rationale for this procedure was based on the presence of a cytotoxic autoantibody with specificity for helper (TH2-) T lymphocytes. Plasmapheresis reduced the autoantibody concentration to undetectable levels, which resulted in an increased number of helper T cells. These T cells provided normal in vitro helper activity. Plasmapheresis did not correct a concomitant suppressor T-cell defect, and the clinical remission ended during the fifth month of exchange therapy.

Original languageEnglish (US)
Pages (from-to)233-235
Number of pages3
JournalBlood
Volume59
Issue number2
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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