Parathyroid hormone-related peptide and the hair cycle - is it the agonists or the antagonists that cause hair growth?

Robert C. Gensure

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

While the effects of PTHrP have been studied for almost 20 years, most of these studies have focused on effects on the termination of the anagen phase, giving an incomplete picture of the overall effect of PTHrP on the hair cycle. PTHrP was determined in several experimental models to promote transition of hair follicles from anagen to catagen phase, which by itself would suggest that PTHrP blockade might prolong the anagen phase and promote hair growth. However, clinical trials with topically applied PTHrP antagonists have been disappointing, leading to a reconsideration of this model. Additional studies performed in mouse models where hair follicles are damaged (alopecia areata, chemotherapy-induced alopecia) suggest that PTHrP has effects early in the hair cycle as well, promoting hair follicles' entry into anagen phase and initiates the hair cycle. While the mechanism of this has yet to be elucidated, it may involve activation of the Wnt pathway. Thus, the overall effect of PTHrP is to stimulate and accelerate the hair cycle, and in the more clinically relevant models of hair loss where hair follicles have been damaged or become quiescent, it is the agonists, not the antagonists, which would be expected to promote hair growth.

Original languageEnglish (US)
Pages (from-to)865-867
Number of pages3
JournalExperimental Dermatology
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2014

Fingerprint

Parathyroid Hormone-Related Protein
Hair
Hair Follicle
Growth
Alopecia
Alopecia Areata
Wnt Signaling Pathway
Chemotherapy
Theoretical Models
Chemical activation
Clinical Trials
Drug Therapy

Keywords

  • Alopecia
  • Anagen
  • Hair follicle
  • Parathyroid hormone
  • Parathyroid hormone-related peptide

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry
  • Medicine(all)

Cite this

Parathyroid hormone-related peptide and the hair cycle - is it the agonists or the antagonists that cause hair growth? / Gensure, Robert C.

In: Experimental Dermatology, Vol. 23, No. 12, 01.12.2014, p. 865-867.

Research output: Contribution to journalArticle

@article{9f8317ee4d1a4896b472f88dd4dd1568,
title = "Parathyroid hormone-related peptide and the hair cycle - is it the agonists or the antagonists that cause hair growth?",
abstract = "While the effects of PTHrP have been studied for almost 20 years, most of these studies have focused on effects on the termination of the anagen phase, giving an incomplete picture of the overall effect of PTHrP on the hair cycle. PTHrP was determined in several experimental models to promote transition of hair follicles from anagen to catagen phase, which by itself would suggest that PTHrP blockade might prolong the anagen phase and promote hair growth. However, clinical trials with topically applied PTHrP antagonists have been disappointing, leading to a reconsideration of this model. Additional studies performed in mouse models where hair follicles are damaged (alopecia areata, chemotherapy-induced alopecia) suggest that PTHrP has effects early in the hair cycle as well, promoting hair follicles' entry into anagen phase and initiates the hair cycle. While the mechanism of this has yet to be elucidated, it may involve activation of the Wnt pathway. Thus, the overall effect of PTHrP is to stimulate and accelerate the hair cycle, and in the more clinically relevant models of hair loss where hair follicles have been damaged or become quiescent, it is the agonists, not the antagonists, which would be expected to promote hair growth.",
keywords = "Alopecia, Anagen, Hair follicle, Parathyroid hormone, Parathyroid hormone-related peptide",
author = "Gensure, {Robert C.}",
year = "2014",
month = "12",
day = "1",
doi = "10.1111/exd.12504",
language = "English (US)",
volume = "23",
pages = "865--867",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Parathyroid hormone-related peptide and the hair cycle - is it the agonists or the antagonists that cause hair growth?

AU - Gensure, Robert C.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - While the effects of PTHrP have been studied for almost 20 years, most of these studies have focused on effects on the termination of the anagen phase, giving an incomplete picture of the overall effect of PTHrP on the hair cycle. PTHrP was determined in several experimental models to promote transition of hair follicles from anagen to catagen phase, which by itself would suggest that PTHrP blockade might prolong the anagen phase and promote hair growth. However, clinical trials with topically applied PTHrP antagonists have been disappointing, leading to a reconsideration of this model. Additional studies performed in mouse models where hair follicles are damaged (alopecia areata, chemotherapy-induced alopecia) suggest that PTHrP has effects early in the hair cycle as well, promoting hair follicles' entry into anagen phase and initiates the hair cycle. While the mechanism of this has yet to be elucidated, it may involve activation of the Wnt pathway. Thus, the overall effect of PTHrP is to stimulate and accelerate the hair cycle, and in the more clinically relevant models of hair loss where hair follicles have been damaged or become quiescent, it is the agonists, not the antagonists, which would be expected to promote hair growth.

AB - While the effects of PTHrP have been studied for almost 20 years, most of these studies have focused on effects on the termination of the anagen phase, giving an incomplete picture of the overall effect of PTHrP on the hair cycle. PTHrP was determined in several experimental models to promote transition of hair follicles from anagen to catagen phase, which by itself would suggest that PTHrP blockade might prolong the anagen phase and promote hair growth. However, clinical trials with topically applied PTHrP antagonists have been disappointing, leading to a reconsideration of this model. Additional studies performed in mouse models where hair follicles are damaged (alopecia areata, chemotherapy-induced alopecia) suggest that PTHrP has effects early in the hair cycle as well, promoting hair follicles' entry into anagen phase and initiates the hair cycle. While the mechanism of this has yet to be elucidated, it may involve activation of the Wnt pathway. Thus, the overall effect of PTHrP is to stimulate and accelerate the hair cycle, and in the more clinically relevant models of hair loss where hair follicles have been damaged or become quiescent, it is the agonists, not the antagonists, which would be expected to promote hair growth.

KW - Alopecia

KW - Anagen

KW - Hair follicle

KW - Parathyroid hormone

KW - Parathyroid hormone-related peptide

UR - http://www.scopus.com/inward/record.url?scp=84913529495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84913529495&partnerID=8YFLogxK

U2 - 10.1111/exd.12504

DO - 10.1111/exd.12504

M3 - Article

VL - 23

SP - 865

EP - 867

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 12

ER -