Parallel genome analysis by two-dimensional DNA typing.

E. Mullaart, G. J. de Vos, G. J. te Meerman, A. G. Uitterlinden, J. Vijg

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

Original languageEnglish (US)
Pages (from-to)469-471
Number of pages3
JournalNature
Volume365
Issue number6445
DOIs
StatePublished - Sep 30 1993
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Parallel genome analysis by two-dimensional DNA typing.'. Together they form a unique fingerprint.

  • Cite this

    Mullaart, E., de Vos, G. J., te Meerman, G. J., Uitterlinden, A. G., & Vijg, J. (1993). Parallel genome analysis by two-dimensional DNA typing. Nature, 365(6445), 469-471. https://doi.org/10.1038/365469a0