Parallel genome analysis by two-dimensional DNA typing.

E. Mullaart, G. J. de Vos, G. J. te Meerman, A. G. Uitterlinden, Jan Vijg

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

Original languageEnglish (US)
Pages (from-to)469-471
Number of pages3
JournalNature
Volume365
Issue number6445
DOIs
StatePublished - Sep 30 1993
Externally publishedYes

Fingerprint

DNA Fingerprinting
Base Pairing
Genome
Costs and Cost Analysis
DNA
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Mullaart, E., de Vos, G. J., te Meerman, G. J., Uitterlinden, A. G., & Vijg, J. (1993). Parallel genome analysis by two-dimensional DNA typing. Nature, 365(6445), 469-471. https://doi.org/10.1038/365469a0

Parallel genome analysis by two-dimensional DNA typing. / Mullaart, E.; de Vos, G. J.; te Meerman, G. J.; Uitterlinden, A. G.; Vijg, Jan.

In: Nature, Vol. 365, No. 6445, 30.09.1993, p. 469-471.

Research output: Contribution to journalArticle

Mullaart, E, de Vos, GJ, te Meerman, GJ, Uitterlinden, AG & Vijg, J 1993, 'Parallel genome analysis by two-dimensional DNA typing.', Nature, vol. 365, no. 6445, pp. 469-471. https://doi.org/10.1038/365469a0
Mullaart E, de Vos GJ, te Meerman GJ, Uitterlinden AG, Vijg J. Parallel genome analysis by two-dimensional DNA typing. Nature. 1993 Sep 30;365(6445):469-471. https://doi.org/10.1038/365469a0
Mullaart, E. ; de Vos, G. J. ; te Meerman, G. J. ; Uitterlinden, A. G. ; Vijg, Jan. / Parallel genome analysis by two-dimensional DNA typing. In: Nature. 1993 ; Vol. 365, No. 6445. pp. 469-471.
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