Abstract
By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.
Original language | English (US) |
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Pages (from-to) | 469-471 |
Number of pages | 3 |
Journal | Nature |
Volume | 365 |
Issue number | 6445 |
DOIs | |
State | Published - Sep 30 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- General