Paradox of pattern separation and adult neurogenesis

A dual role for new neurons balancing memory resolution and robustness

Stephen T. Johnston, Matthew Shtrahman, Sarah Parylak, J. Tiago Goncalves, Fred H. Gage

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Hippocampal adult neurogenesis is thought to subserve pattern separation, the process by which similar patterns of neuronal inputs are transformed into distinct neuronal representations, permitting the discrimination of highly similar stimuli in hippocampus-dependent tasks. However, the mechanism by which immature adult-born dentate granule neurons cells (abDGCs) perform this function remains unknown. Two theories of abDGC function, one by which abDGCs modulate and sparsify activity in the dentate gyrus and one by which abDGCs act as autonomous coding units, are generally suggested to be mutually exclusive. This review suggests that these two mechanisms work in tandem to dynamically regulate memory resolution while avoiding memory interference and maintaining memory robustness.

Original languageEnglish (US)
Pages (from-to)60-68
Number of pages9
JournalNeurobiology of Learning and Memory
Volume129
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Fingerprint

Neurogenesis
Neurons
Dentate Gyrus
Hippocampus

Keywords

  • Adult neurogenesis
  • Dentate gyrus
  • Memory resolution
  • Memory robustness
  • Pattern completion
  • Pattern separation

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Paradox of pattern separation and adult neurogenesis : A dual role for new neurons balancing memory resolution and robustness. / Johnston, Stephen T.; Shtrahman, Matthew; Parylak, Sarah; Goncalves, J. Tiago; Gage, Fred H.

In: Neurobiology of Learning and Memory, Vol. 129, 01.03.2016, p. 60-68.

Research output: Contribution to journalReview article

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