Paired kidney donor exchanges and antibody reduction therapy

Novel methods to ameliorate disparate access to living donor kidney transplantation in ethnic minorities

Joseph K. Melancon, Lee S. Cummings, Jay A. Graham, Sandra Rosen-Bronson, Jimmy Light, Chirag S. Desai, Raffaele Girlanda, Seyed Ghasemian, Joseph Africa, Lynt B. Johnson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Currently ethnic minority patients comprise 60% of patients listed for kidney transplantation in the US; however, they receive only 55% of deceased donor renal transplants and 25% of living donor renal transplants. Ethnic disparities in access to kidney transplantation result in increased morbidity and mortality for minority patients with end-stage renal disease. Because these patients remain dialysis dependent for longer durations, they are more prone to the development of HLA antibodies that further delay the possibility of receiving a successful kidney transplant. Study Design: Two to 4 pretransplant and post-transplant plasma exchanges and IV immunoglobulin were used to lower donor-specific antibody levels to less than 1:16 dilution; cell lytic therapy was used additionally in some cases. Match pairing by virtual cross-matching was performed to identify the maximal exchange benefit. Sixty candidates for renal transplantation were placed into 4 paired kidney exchanges and/or underwent antibody reduction therapy. Results: Sixty living donor renal transplants were performed by paired exchange pools and/or antibody reduction therapy in recipients whose original intended donors had ABO or HLA incompatibilities or both (24 desensitization and 36 paired kidney exchanges). Successful transplants were performed in 38 ethnic minorities, of which 33 were African American. Twenty-two recipients were white. Graft and patient survival was 100% at 6 months; graft function (mean serum creatinine 1.4 g/dL) and acute rejection rates (20%) have been comparable to traditional live donor kidney transplantation. Conclusions: Paired kidney donor exchange pools with antibody reduction therapy can allow successful transplant in difficult to match recipients. This approach can address kidney transplant disparities.

Original languageEnglish (US)
Pages (from-to)740-745
Number of pages6
JournalJournal of the American College of Surgeons
Volume212
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

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Living Donors
Kidney Transplantation
Tissue Donors
Transplants
Kidney
Antibodies
Therapeutics
Plasma Exchange
Intravenous Immunoglobulins
Graft Survival
Cell- and Tissue-Based Therapy
African Americans
Chronic Kidney Failure
Dialysis
Creatinine
Morbidity
Mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Paired kidney donor exchanges and antibody reduction therapy : Novel methods to ameliorate disparate access to living donor kidney transplantation in ethnic minorities. / Melancon, Joseph K.; Cummings, Lee S.; Graham, Jay A.; Rosen-Bronson, Sandra; Light, Jimmy; Desai, Chirag S.; Girlanda, Raffaele; Ghasemian, Seyed; Africa, Joseph; Johnson, Lynt B.

In: Journal of the American College of Surgeons, Vol. 212, No. 4, 04.2011, p. 740-745.

Research output: Contribution to journalArticle

Melancon, Joseph K. ; Cummings, Lee S. ; Graham, Jay A. ; Rosen-Bronson, Sandra ; Light, Jimmy ; Desai, Chirag S. ; Girlanda, Raffaele ; Ghasemian, Seyed ; Africa, Joseph ; Johnson, Lynt B. / Paired kidney donor exchanges and antibody reduction therapy : Novel methods to ameliorate disparate access to living donor kidney transplantation in ethnic minorities. In: Journal of the American College of Surgeons. 2011 ; Vol. 212, No. 4. pp. 740-745.
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AU - Rosen-Bronson, Sandra

AU - Light, Jimmy

AU - Desai, Chirag S.

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