Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice

Eugenie Dubnau, John Chan, Catherine Raynaud, Vellore P. Mohan, Marie Antoinette Lanéelle, Keming Yu, Annaik Quémard, Issar Smith, Mamadou Daffé

Research output: Contribution to journalArticle

224 Scopus citations

Abstract

Members of the Mycobacterium tuberculosis group synthesize a family of long-chain fatty acids, mycolic acids, which are located in the cell envelope. These include the non-oxygenated α-mycolic acid and the oxygenated keto- and methoxymycolic acids. The function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4) gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound alterations in its envelope permeability and is attenuated in mice.

Original languageEnglish (US)
Pages (from-to)630-637
Number of pages8
JournalMolecular Microbiology
Volume36
Issue number3
DOIs
StatePublished - May 24 2000

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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    Dubnau, E., Chan, J., Raynaud, C., Mohan, V. P., Lanéelle, M. A., Yu, K., Quémard, A., Smith, I., & Daffé, M. (2000). Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice. Molecular Microbiology, 36(3), 630-637. https://doi.org/10.1046/j.1365-2958.2000.01882.x