TY - JOUR
T1 - Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice
AU - Dubnau, Eugenie
AU - Chan, John
AU - Raynaud, Catherine
AU - Mohan, Vellore P.
AU - Lanéelle, Marie Antoinette
AU - Yu, Keming
AU - Quémard, Annaik
AU - Smith, Issar
AU - Daffé, Mamadou
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Members of the Mycobacterium tuberculosis group synthesize a family of long-chain fatty acids, mycolic acids, which are located in the cell envelope. These include the non-oxygenated α-mycolic acid and the oxygenated keto- and methoxymycolic acids. The function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4) gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound alterations in its envelope permeability and is attenuated in mice.
AB - Members of the Mycobacterium tuberculosis group synthesize a family of long-chain fatty acids, mycolic acids, which are located in the cell envelope. These include the non-oxygenated α-mycolic acid and the oxygenated keto- and methoxymycolic acids. The function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4) gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound alterations in its envelope permeability and is attenuated in mice.
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U2 - 10.1046/j.1365-2958.2000.01882.x
DO - 10.1046/j.1365-2958.2000.01882.x
M3 - Article
C2 - 10844652
AN - SCOPUS:0034073375
SN - 0950-382X
VL - 36
SP - 630
EP - 637
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 3
ER -
