The oxygen consumption on the membranous cochlea of the sh-1/sh-1 was significantly less than that of the CBA-J/CBA-J. Other tissues showed no difference in their oxygen consumption. Shaker-1 (sh-1/sh-1) mice are a strain of mice with a progressive deafness which is inherited as an autosomal recessive. The gene for shaker-1 is located on the first linkage group (Sidman et al, 1965). There have been several studies in which the physiology (Mikaelian & Ruben, 1964; Brown & Ruben, 1969), behavior (Hack, 1968), histology (Gruneberg et al, 1940; Deol, 1956), and electron microscopy (Kikuchi & Hilding, 1965 and 1967) of the sh-1/sh-1 have been described. The present study is an examination of the ability of the membranous cochlea of the deaf sh-1/sh-1 to utilize oxygen. Other tissues were examined to determine if the shaker-1 gene affected them in a similar fashion. The CBA-J/CBA-J mouse was used as a comparison as some of the other studies done with the sh-1/sh-1 also used this method.
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