Oxygen consumption of the membranous cochlea and other tissues in shaker-1 (sh-1/sh-1) and normal (CBA-j/CBA-j) mice

Y. Sato, M. Sato, R. J. Ruben

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Abstract

The oxygen consumption on the membranous cochlea of the sh-1/sh-1 was significantly less than that of the CBA-J/CBA-J. Other tissues showed no difference in their oxygen consumption. Shaker-1 (sh-1/sh-1) mice are a strain of mice with a progressive deafness which is inherited as an autosomal recessive. The gene for shaker-1 is located on the first linkage group (Sidman et al, 1965). There have been several studies in which the physiology (Mikaelian & Ruben, 1964; Brown & Ruben, 1969), behavior (Hack, 1968), histology (Gruneberg et al, 1940; Deol, 1956), and electron microscopy (Kikuchi & Hilding, 1965 and 1967) of the sh-1/sh-1 have been described. The present study is an examination of the ability of the membranous cochlea of the deaf sh-1/sh-1 to utilize oxygen. Other tissues were examined to determine if the shaker-1 gene affected them in a similar fashion. The CBA-J/CBA-J mouse was used as a comparison as some of the other studies done with the sh-1/sh-1 also used this method.

Original languageEnglish (US)
Pages (from-to)239-242
Number of pages4
JournalActa Oto-Laryngologica
Volume68
Issue number1-6
DOIs
Publication statusPublished - Jan 1 1969

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ASJC Scopus subject areas

  • Otorhinolaryngology

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