Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus

Shyam Prabhakaran; Matthew Bramlage; Mark A. Edgar; Betty Diamond; John A. Hardin; Bruce T. Volpe

Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus

Shyam Prabhakaran, Matthew Bramlage, Mark A. Edgar, Betty Diamond, John A. Hardin, Bruce T. Volpe

Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus.

Original language	English (US)
Pages (from-to)	1843-1845
Number of pages	3
Journal	Journal of Rheumatology
Volume	32
Issue number	9
State	Published - Sep 2005

Keywords

Autoantibodies
Immunology
Nervous system
Pathology
Systemic lupus erythematosus

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

Cite this

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title = "Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus",

abstract = "We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus.",

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AU - Prabhakaran, Shyam

AU - Bramlage, Matthew

AU - Edgar, Mark A.

AU - Diamond, Betty

AU - Hardin, John A.

AU - Volpe, Bruce T.

PY - 2005/9

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N2 - We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus.

AB - We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus.

KW - Autoantibodies

KW - Immunology

KW - Nervous system

KW - Pathology

KW - Systemic lupus erythematosus

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ER -

Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus

Abstract

Keywords

ASJC Scopus subject areas

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