Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus

Shyam Prabhakaran, Matthew Bramlage, Mark A. Edgar, Betty Diamond, John A. Hardin, Bruce T. Volpe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus.

Original languageEnglish (US)
Pages (from-to)1843-1845
Number of pages3
JournalJournal of Rheumatology
Volume32
Issue number9
StatePublished - Sep 2005

Fingerprint

Leukoencephalopathies
Brain Edema
Brain
Systemic Lupus Erythematosus
Autopsy
Edema
Central Nervous System
Magnetic Resonance Imaging
Therapeutics
White Matter

Keywords

  • Autoantibodies
  • Immunology
  • Nervous system
  • Pathology
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Prabhakaran, S., Bramlage, M., Edgar, M. A., Diamond, B., Hardin, J. A., & Volpe, B. T. (2005). Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus. Journal of Rheumatology, 32(9), 1843-1845.

Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus. / Prabhakaran, Shyam; Bramlage, Matthew; Edgar, Mark A.; Diamond, Betty; Hardin, John A.; Volpe, Bruce T.

In: Journal of Rheumatology, Vol. 32, No. 9, 09.2005, p. 1843-1845.

Research output: Contribution to journalArticle

Prabhakaran, S, Bramlage, M, Edgar, MA, Diamond, B, Hardin, JA & Volpe, BT 2005, 'Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus', Journal of Rheumatology, vol. 32, no. 9, pp. 1843-1845.
Prabhakaran S, Bramlage M, Edgar MA, Diamond B, Hardin JA, Volpe BT. Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus. Journal of Rheumatology. 2005 Sep;32(9):1843-1845.
Prabhakaran, Shyam ; Bramlage, Matthew ; Edgar, Mark A. ; Diamond, Betty ; Hardin, John A. ; Volpe, Bruce T. / Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus. In: Journal of Rheumatology. 2005 ; Vol. 32, No. 9. pp. 1843-1845.
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