Overweight Men

Clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Julia Keltz, Athena Zapantis, Sangita K. Jindal, Harry J. Lieman, Nanette Santoro, Alex J. Polotsky

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Purpose: To evaluate if elevated male body mass influences success after assisted reproductive technologies Methods: Retrospective study of 290 cycles. Results: Male body mass index greater than 25.0 kg/m2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07-0.69] vs. 0.75 [0.38-1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass. Conclusion: In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalJournal of Assisted Reproduction and Genetics
Volume27
Issue number9-10
DOIs
StatePublished - Sep 2010

Fingerprint

Intracytoplasmic Sperm Injections
Pregnancy
Fertilization in Vitro
Spermatozoa
Sperm-Ovum Interactions
Assisted Reproductive Techniques
Body Mass Index
Embryonic Structures
Retrospective Studies
Obesity
Logistic Models
Odds Ratio

Keywords

  • Assisted reproduction
  • In vitro fertilization
  • IVF/ICSI outcome
  • Male obesity

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)

Cite this

Overweight Men : Clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. / Keltz, Julia; Zapantis, Athena; Jindal, Sangita K.; Lieman, Harry J.; Santoro, Nanette; Polotsky, Alex J.

In: Journal of Assisted Reproduction and Genetics, Vol. 27, No. 9-10, 09.2010, p. 539-544.

Research output: Contribution to journalArticle

Keltz, Julia ; Zapantis, Athena ; Jindal, Sangita K. ; Lieman, Harry J. ; Santoro, Nanette ; Polotsky, Alex J. / Overweight Men : Clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. In: Journal of Assisted Reproduction and Genetics. 2010 ; Vol. 27, No. 9-10. pp. 539-544.
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