Overweight Men: Clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Julia Keltz, Athena Zapantis, Sangita K. Jindal, Harry J. Lieman, Nanette Santoro, Alex J. Polotsky

Research output: Contribution to journalArticle

69 Scopus citations


Purpose: To evaluate if elevated male body mass influences success after assisted reproductive technologies Methods: Retrospective study of 290 cycles. Results: Male body mass index greater than 25.0 kg/m2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07-0.69] vs. 0.75 [0.38-1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass. Conclusion: In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalJournal of Assisted Reproduction and Genetics
Issue number9-10
Publication statusPublished - Sep 1 2010



  • Assisted reproduction
  • IVF/ICSI outcome
  • In vitro fertilization
  • Male obesity

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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