Overweight Men: Clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Julia Keltz, Athena Zapantis, Sangita K. Jindal, Harry J. Lieman, Nanette Santoro, Alex J. Polotsky

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Purpose: To evaluate if elevated male body mass influences success after assisted reproductive technologies Methods: Retrospective study of 290 cycles. Results: Male body mass index greater than 25.0 kg/m2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07-0.69] vs. 0.75 [0.38-1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass. Conclusion: In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalJournal of Assisted Reproduction and Genetics
Volume27
Issue number9-10
DOIs
StatePublished - Sep 2010

Fingerprint

Intracytoplasmic Sperm Injections
Pregnancy
Fertilization in Vitro
Spermatozoa
Sperm-Ovum Interactions
Assisted Reproductive Techniques
Body Mass Index
Embryonic Structures
Retrospective Studies
Obesity
Logistic Models
Odds Ratio

Keywords

  • Assisted reproduction
  • In vitro fertilization
  • IVF/ICSI outcome
  • Male obesity

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)

Cite this

Overweight Men : Clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. / Keltz, Julia; Zapantis, Athena; Jindal, Sangita K.; Lieman, Harry J.; Santoro, Nanette; Polotsky, Alex J.

In: Journal of Assisted Reproduction and Genetics, Vol. 27, No. 9-10, 09.2010, p. 539-544.

Research output: Contribution to journalArticle

Keltz, Julia ; Zapantis, Athena ; Jindal, Sangita K. ; Lieman, Harry J. ; Santoro, Nanette ; Polotsky, Alex J. / Overweight Men : Clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. In: Journal of Assisted Reproduction and Genetics. 2010 ; Vol. 27, No. 9-10. pp. 539-544.
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