TY - JOUR
T1 - Over 15 years
T2 - the advancement of transcatheter aortic valve replacement
AU - Cahill, Thomas J.
AU - Terre, Juan A.
AU - George, Isaac
N1 - Publisher Copyright:
© 2020. Annals of Cardiothoracic Surgery. All rights reserved.
PY - 2020
Y1 - 2020
N2 - The management of aortic stenosis has been revolutionized by transcatheter aortic valve replacement (TAVR). Initially only undertaken in patients at prohibitive or high surgical risk, as the evidence base and indications have expanded, TAVR is now approved and undertaken in patients at all risk levels. Evolution of valve technology, delivery systems and pathways for patient work-up have been rapid, with associated reductions in the complication profile, particularly vascular complications. Challenges remain as TAVR continues to advance, however, specifically achieving further reduction in paravalvular regurgitation, the requirement for permanent pacemaker implantation, and balancing the risks of thrombosis and bleeding. In this review, we outline the historical advances leading to contemporary TAVR practice, and discuss the future trajectory.
AB - The management of aortic stenosis has been revolutionized by transcatheter aortic valve replacement (TAVR). Initially only undertaken in patients at prohibitive or high surgical risk, as the evidence base and indications have expanded, TAVR is now approved and undertaken in patients at all risk levels. Evolution of valve technology, delivery systems and pathways for patient work-up have been rapid, with associated reductions in the complication profile, particularly vascular complications. Challenges remain as TAVR continues to advance, however, specifically achieving further reduction in paravalvular regurgitation, the requirement for permanent pacemaker implantation, and balancing the risks of thrombosis and bleeding. In this review, we outline the historical advances leading to contemporary TAVR practice, and discuss the future trajectory.
KW - Transcatheter aortic valve replacement (TAVR)
KW - aortic stenosis
KW - surgical aortic valve replacement (SAVR)
KW - valvular heart disease
UR - http://www.scopus.com/inward/record.url?scp=85102368150&partnerID=8YFLogxK
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U2 - 10.21037/acs-2020-av-24
DO - 10.21037/acs-2020-av-24
M3 - Article
AN - SCOPUS:85102368150
SN - 2225-319X
VL - 9
SP - 442
EP - 451
JO - Annals of Cardiothoracic Surgery
JF - Annals of Cardiothoracic Surgery
IS - 6
ER -