Outcomes of transcatheter tricuspid valve intervention by right ventricular function: A multicentre propensity-matched analysis

Florian Schlotter, Mizuki Miura, Karl Patrik Kresoja, Brunilda Alushi, Hannes Alessandrini, Adrian Attinger-Toller, Christian Besler, Luigi Biasco, Daniel Braun, Eric Brochet, Kim A. Connelly, Sabine De Bruijn, Paolo Denti, Rodrigo Estevez-Loureiro, Neil Fam, Mara Gavazzoni, Dominique Himbert, Edwin Ho, Jean Michel Juliard, Daniel KalbacherRyan Kaple, Felix Kreidel, Mohamed Azeem Latib, Edith Lubos, Sebastian Ludwig, Michael Mehr, Vanessa Monivas, Tamin Nazif, Georg Nickenig, Giovanni Pedrazzini, Alberto Pozzoli, Fabien Praz, Rishi Puri, Josep Rodés-Cabau, Karl Philipp Rommel, Ulrich Schäfer, Joachim Schofer, Horst Sievert, Gilbert H.L. Tang, Holger Thiele, Matthias Unterhuber, Alec Vahanian, Ralph Stephan Von Bardeleben, Maximilian Von Roeder, John G. Webb, Marcel Weber, Mirjam G. Wild, Stephan Windecker, Michel Zuber, Jörg Hausleiter, Francesco Maisano, Martin B. Leon, Rebecca T. Hahn, Alexander Lauten, Maurizio Taramasso, Philipp Lurz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Tricuspid regurgitation (TR) has a poor prognosis and limited treatment options and is frequently accompanied by right ventricular (RV) dysfunction. Transcatheter tricuspid valve interventions (TTVI) to reduce TR have been shown to be safe and feasible with encouraging early results. Patient selection for TTVI remains challenging, with the role of right ventricular (RV) function being unknown. Aims: The aims of this study were 1) to investigate survival in a TTVI-treated patient population and a conservatively treated TR population, and 2) to evaluate the outcome of TTVI as compared to conservative treatment stratified according to the degree of RV function. Methods: We studied 684 patients from the multicentre TriValve cohort (TTVI cohort) and compared them to 914 conservatively treated patients from two tertiary care centres. Propensity matching identified 213 pairs of patients with severe TR. As we observed a non-linear relationship of RV function and TTVI outcome, we stratified patients according to tricuspid annular plane systolic excursion (TAPSE) to preserved (TAPSE >17 mm), mid-range (TAPSE 13-17 mm) and reduced (TAPSE <13 mm) RV function. The primary outcome was one-year all-cause mortality. Results: TTVI was associated with a survival benefit in patients with severe TR when compared to matched controls (one-year mortality rate: 13.1% vs 25.8%; p=0.031). Of the three RV subgroups, only in patients with mid-range RV function was TTVI associated with an improved survival (p log-rank 0.004). In these patients, procedural success was associated with a reduced hazard ratio for all-cause mortality (HR 0.22; 95% CI: 0.09, 0.57). Conclusions: TTVI is associated with reduced mortality compared to conservative therapy and might exert its highest treatment effect in patients with mid-range reduced RV function.

Original languageEnglish (US)
Pages (from-to)343-352
Number of pages10
JournalEuroIntervention
Volume17
Issue number4
DOIs
StatePublished - Jul 2021

Keywords

  • Chronic heart failure
  • Tricuspid disease
  • TTVI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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