Outcomes of donor evaluation in adult-to-adult living donor liver transplantation

James F. Trotter, Karen A. Wisniewski, Norah A. Terrault, James E. Everhart, Milan Kinkhabwala, Robert M. Weinrieb, Jeffrey H. Fair, Robert A. Fisher, Alan J. Koffron, Sammy Saab, Robert M. Merion

Research output: Contribution to journalArticle

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Abstract

The purpose of donor evaluation for adult-to-adult living donor liver transplantation (LDLT) is to discover medical conditions that could increase the donor postoperative risk of complications and to determine whether the donor can yield a suitable graft for the recipient. We report the outcomes of LDLT donor candidates evaluated in a large multicenter study of LDLT. The records of all donor candidates and their respective recipients between 1998 and 2003 were reviewed as part of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). The outcomes of the evaluation were recorded along with demographic data on the donors and recipients. Of the 1011 donor candidates evaluated, 405 (40%) were accepted for donation. The donor characteristics associated with acceptance (P < 0.05) were younger age, lower body mass index, and biological or spousal relationship to the recipient. Recipient characteristics associated with donor acceptance were younger age, lower Model for End-stage Liver Disease score, and shorter time from listing to first donor evaluation. Other predictors of donor acceptance included earlier year of evaluation and transplant center. Conclusion: Both donor and recipient features appear to affect acceptance for LDLT. These findings may aid the donor evaluation process and allow an objective assessment of the likelihood of donor candidate acceptance.

Original languageEnglish (US)
Pages (from-to)1476-1484
Number of pages9
JournalHepatology
Volume46
Issue number5
DOIs
StatePublished - Nov 2007
Externally publishedYes

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Living Donors
Liver Transplantation
Tissue Donors
Transplants
End Stage Liver Disease
Multicenter Studies
Body Mass Index
Cohort Studies

ASJC Scopus subject areas

  • Hepatology

Cite this

Trotter, J. F., Wisniewski, K. A., Terrault, N. A., Everhart, J. E., Kinkhabwala, M., Weinrieb, R. M., ... Merion, R. M. (2007). Outcomes of donor evaluation in adult-to-adult living donor liver transplantation. Hepatology, 46(5), 1476-1484. https://doi.org/10.1002/hep.21845

Outcomes of donor evaluation in adult-to-adult living donor liver transplantation. / Trotter, James F.; Wisniewski, Karen A.; Terrault, Norah A.; Everhart, James E.; Kinkhabwala, Milan; Weinrieb, Robert M.; Fair, Jeffrey H.; Fisher, Robert A.; Koffron, Alan J.; Saab, Sammy; Merion, Robert M.

In: Hepatology, Vol. 46, No. 5, 11.2007, p. 1476-1484.

Research output: Contribution to journalArticle

Trotter, JF, Wisniewski, KA, Terrault, NA, Everhart, JE, Kinkhabwala, M, Weinrieb, RM, Fair, JH, Fisher, RA, Koffron, AJ, Saab, S & Merion, RM 2007, 'Outcomes of donor evaluation in adult-to-adult living donor liver transplantation', Hepatology, vol. 46, no. 5, pp. 1476-1484. https://doi.org/10.1002/hep.21845
Trotter JF, Wisniewski KA, Terrault NA, Everhart JE, Kinkhabwala M, Weinrieb RM et al. Outcomes of donor evaluation in adult-to-adult living donor liver transplantation. Hepatology. 2007 Nov;46(5):1476-1484. https://doi.org/10.1002/hep.21845
Trotter, James F. ; Wisniewski, Karen A. ; Terrault, Norah A. ; Everhart, James E. ; Kinkhabwala, Milan ; Weinrieb, Robert M. ; Fair, Jeffrey H. ; Fisher, Robert A. ; Koffron, Alan J. ; Saab, Sammy ; Merion, Robert M. / Outcomes of donor evaluation in adult-to-adult living donor liver transplantation. In: Hepatology. 2007 ; Vol. 46, No. 5. pp. 1476-1484.
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