Outcome of infants diagnosed with 3-methyl-crotonyl-CoA-carboxylase deficiency by newborn screening

Georgianne L. Arnold, Denise Salazar, Julie A. Neidich, Pim Suwannarat, Brett H. Graham, Uta Lichter-Konecki, Annet M. Bosch, Kristina Cusmano-Ozog, Greg Enns, Erica L. Wright, Brendan C. Lanpher, Natalie N. Owen, Mark H. Lipson, Roberto Cerone, Paul A. Levy, Lee Jun C Wong, Antal Dezsofi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction: 3-Methyl CoA carboxylase (3-MCC) deficiency is an inborn error of metabolism in the catabolism of the amino acid leucine. Original reports suggested this disorder was associated with significant neurological and biochemical effects. However newborn screening has identified a higher than expected incidence of this disorder with apparent normal outcome in most cases. Method: A retrospective analysis of thirty-five cases of 3-MCC deficiency identified by newborn screening and diagnosed by enzyme or molecular analysis. Results: There was a strong inverse correlation between initial C5OH level and residual enzyme activity. A few reports of hypoglycemia, ketosis, poor feeding/failure to thrive or fasting intolerance were reported, but there was no clear relationship between symptoms and residual enzyme activity. Developmental outcome included several children with mental retardation (including one with Down syndrome and one with schizencephaly) and two with Autism Spectrum disorders but there was no apparent relationship to residual enzyme activity. Free carnitine deficiency was relatively common. Discussion: Although residual enzyme activity was clearly related to metabolite elevation, there was no apparent relationship with other measures of outcome. The number of reports of neurologic abnormalities or metabolic symptoms (poor feeding, hypoglycemia, fasting intolerance, etc.) is concerning, but the significance is unclear in this retrospective sample.

Original languageEnglish (US)
Pages (from-to)439-441
Number of pages3
JournalMolecular Genetics and Metabolism
Volume106
Issue number4
DOIs
StatePublished - Aug 2012

Fingerprint

Enzyme activity
Screening
Newborn Infant
Enzymes
Coenzyme A
Hypoglycemia
Carnitine
Nervous System Malformations
Metabolites
Inborn Errors Metabolism
Failure to Thrive
Ketosis
Metabolism
Leucine
Down Syndrome
Intellectual Disability
Fasting
Amino Acids
Outcome Assessment (Health Care)
crotonyl-coenzyme A

Keywords

  • 3-Methylcrotonyl CoA carboxylase deficiency
  • Newborn screening
  • Organic acidemia

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Arnold, G. L., Salazar, D., Neidich, J. A., Suwannarat, P., Graham, B. H., Lichter-Konecki, U., ... Dezsofi, A. (2012). Outcome of infants diagnosed with 3-methyl-crotonyl-CoA-carboxylase deficiency by newborn screening. Molecular Genetics and Metabolism, 106(4), 439-441. https://doi.org/10.1016/j.ymgme.2012.04.006

Outcome of infants diagnosed with 3-methyl-crotonyl-CoA-carboxylase deficiency by newborn screening. / Arnold, Georgianne L.; Salazar, Denise; Neidich, Julie A.; Suwannarat, Pim; Graham, Brett H.; Lichter-Konecki, Uta; Bosch, Annet M.; Cusmano-Ozog, Kristina; Enns, Greg; Wright, Erica L.; Lanpher, Brendan C.; Owen, Natalie N.; Lipson, Mark H.; Cerone, Roberto; Levy, Paul A.; Wong, Lee Jun C; Dezsofi, Antal.

In: Molecular Genetics and Metabolism, Vol. 106, No. 4, 08.2012, p. 439-441.

Research output: Contribution to journalArticle

Arnold, GL, Salazar, D, Neidich, JA, Suwannarat, P, Graham, BH, Lichter-Konecki, U, Bosch, AM, Cusmano-Ozog, K, Enns, G, Wright, EL, Lanpher, BC, Owen, NN, Lipson, MH, Cerone, R, Levy, PA, Wong, LJC & Dezsofi, A 2012, 'Outcome of infants diagnosed with 3-methyl-crotonyl-CoA-carboxylase deficiency by newborn screening', Molecular Genetics and Metabolism, vol. 106, no. 4, pp. 439-441. https://doi.org/10.1016/j.ymgme.2012.04.006
Arnold, Georgianne L. ; Salazar, Denise ; Neidich, Julie A. ; Suwannarat, Pim ; Graham, Brett H. ; Lichter-Konecki, Uta ; Bosch, Annet M. ; Cusmano-Ozog, Kristina ; Enns, Greg ; Wright, Erica L. ; Lanpher, Brendan C. ; Owen, Natalie N. ; Lipson, Mark H. ; Cerone, Roberto ; Levy, Paul A. ; Wong, Lee Jun C ; Dezsofi, Antal. / Outcome of infants diagnosed with 3-methyl-crotonyl-CoA-carboxylase deficiency by newborn screening. In: Molecular Genetics and Metabolism. 2012 ; Vol. 106, No. 4. pp. 439-441.
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AU - Salazar, Denise

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AU - Suwannarat, Pim

AU - Graham, Brett H.

AU - Lichter-Konecki, Uta

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AU - Enns, Greg

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AU - Lanpher, Brendan C.

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