The application of knowledge to the care of individual patients has evolved. During most of recorded history it was based on experience, i.e., case reports; not until the middle of the 20th century did randomized controlled trials (RCTs) come to be the "gold standard." But by the beginning of the 21st century, the limitations of RCTs and their synthesis, the meta analysis, have been recognized with regard to their applicability to an individual patient. With the intense increase in our knowledge base, medicine now can be personalized beyond the possibilities of earlier periods. The personalized medicine approach requires evaluation of four parameters: the individual patient's intrinsic susceptibility, intrinsic morbidity, extrinsic susceptibility, and extrinsic morbidity. The characteristics of the disease agent?how much and its virulence?must also be factored in. The application of the knowledge of intrinsic and extrinsic risk factors and their effect on susceptibility and morbidity for an individual with otitis media will be presented. These individualized data define the intervention, which is instituted based upon whether there is a high susceptibility and/or morbidity or a low susceptibility and/or morbidity from the aggregate of the intrinsic and extrinsic risk factors.
|Original language||English (US)|
|Journal||Keio Journal of Medicine|
|State||Published - Jun 1 2011|
ASJC Scopus subject areas