Osteocalcin in human serum

A circadian rhythm

C. M. Gundberg, Morri E. Markowitz, M. Mizruchi, J. F. Rosen

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Osteocalcin, the vitamin K-dependent protein synthesized in bone, is found in blood. The level of circulating osteocalcin has recently been used as an indicator of the rate of bone turnover. We measured serum osteocalcin during 24-h periods in 6 normal 20- to 30-yr-old men and 4 women. Blood was sampled via an indwelling venous catheter every 30 or 60 min for 24 h. Circadian rhythmicity in circulating osteocalcin was found in 9 of the 10 individuals studied. Osteocalcin levels fell during the morning, rose in the afternoon and early evening, and reached a peak nocturnally. There were no consistent correlations between osteocalcin concentrations and circulating levels of ionized calcium, total calcium, or inorganic phosphate in the subjects tested. This study illustrates the importance of regulating the time of blood sampling for osteocalcin determinations in clinical investigations of metabolic bone disease.

Original languageEnglish (US)
Pages (from-to)736-739
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume60
Issue number4
StatePublished - 1985

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Osteocalcin
Circadian Rhythm
Serum
Bone
Blood
Calcium
Indwelling Catheters
Vitamin K
Bone Remodeling
Metabolic Bone Diseases
Catheters
Periodicity
Phosphates
Sampling
Bone and Bones
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Osteocalcin in human serum : A circadian rhythm. / Gundberg, C. M.; Markowitz, Morri E.; Mizruchi, M.; Rosen, J. F.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 60, No. 4, 1985, p. 736-739.

Research output: Contribution to journalArticle

Gundberg, CM, Markowitz, ME, Mizruchi, M & Rosen, JF 1985, 'Osteocalcin in human serum: A circadian rhythm', Journal of Clinical Endocrinology and Metabolism, vol. 60, no. 4, pp. 736-739.
Gundberg, C. M. ; Markowitz, Morri E. ; Mizruchi, M. ; Rosen, J. F. / Osteocalcin in human serum : A circadian rhythm. In: Journal of Clinical Endocrinology and Metabolism. 1985 ; Vol. 60, No. 4. pp. 736-739.
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