Origins of highly mosaic mycobacteriophage genomes

Marisa L. Pedulla, Michael E. Ford, Jennifer M. Houtz, Tharun Karthikeyan, Curtis Wadsworth, John A. Lewis, Debbie Jacobs-Sera, Jacob Falbo, Joseph Gross, Nicholas R. Pannunzio, William Brucker, Vanaja Kumar, Jayasankar Kandasamy, Lauren Keenan, Svetsoslav Bardarov, Jordan Kriakov, Jeffrey G. Lawrence, William R. Jacobs, Roger W. Hendrix, Graham F. Hatfull

Research output: Contribution to journalArticle

426 Citations (Scopus)

Abstract

Bacteriophages are the most abundant organisms in the biosphere and play major roles in the ecological balance of microbial life. The genomic sequences of ten newly isolated mycobacteriophages suggest that the bacteriophage population as a whole is amazingly diverse and may represent the largest unexplored reservoir of sequence information in the biosphere. Genomic comparison of these mycobacteriophages contributes to our understanding of the mechanisms of viral evolution and provides compelling evidence for the role of illegitimate recombination in horizontal genetic exchange. The promiscuity of these recombination events results in the inclusion of many unexpected genes including those implicated in mycobacterial latency, the cellular and immune responses to mycobacterial infections, and autoimmune diseases such as human lupus. While the role of phages as vehicles of toxin genes is well established, these observations suggest a much broader involvement of phages in bacterial virulence and the host response to bacterial infections.

Original languageEnglish (US)
Pages (from-to)171-182
Number of pages12
JournalCell
Volume113
Issue number2
DOIs
StatePublished - Apr 18 2003

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Mycobacteriophages
Bacteriophages
Genes
Genome
Genetic Recombination
Bacterial Infections
Cellular Immunity
Autoimmune Diseases
Virulence
Infection
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pedulla, M. L., Ford, M. E., Houtz, J. M., Karthikeyan, T., Wadsworth, C., Lewis, J. A., ... Hatfull, G. F. (2003). Origins of highly mosaic mycobacteriophage genomes. Cell, 113(2), 171-182. https://doi.org/10.1016/S0092-8674(03)00233-2

Origins of highly mosaic mycobacteriophage genomes. / Pedulla, Marisa L.; Ford, Michael E.; Houtz, Jennifer M.; Karthikeyan, Tharun; Wadsworth, Curtis; Lewis, John A.; Jacobs-Sera, Debbie; Falbo, Jacob; Gross, Joseph; Pannunzio, Nicholas R.; Brucker, William; Kumar, Vanaja; Kandasamy, Jayasankar; Keenan, Lauren; Bardarov, Svetsoslav; Kriakov, Jordan; Lawrence, Jeffrey G.; Jacobs, William R.; Hendrix, Roger W.; Hatfull, Graham F.

In: Cell, Vol. 113, No. 2, 18.04.2003, p. 171-182.

Research output: Contribution to journalArticle

Pedulla, ML, Ford, ME, Houtz, JM, Karthikeyan, T, Wadsworth, C, Lewis, JA, Jacobs-Sera, D, Falbo, J, Gross, J, Pannunzio, NR, Brucker, W, Kumar, V, Kandasamy, J, Keenan, L, Bardarov, S, Kriakov, J, Lawrence, JG, Jacobs, WR, Hendrix, RW & Hatfull, GF 2003, 'Origins of highly mosaic mycobacteriophage genomes', Cell, vol. 113, no. 2, pp. 171-182. https://doi.org/10.1016/S0092-8674(03)00233-2
Pedulla ML, Ford ME, Houtz JM, Karthikeyan T, Wadsworth C, Lewis JA et al. Origins of highly mosaic mycobacteriophage genomes. Cell. 2003 Apr 18;113(2):171-182. https://doi.org/10.1016/S0092-8674(03)00233-2
Pedulla, Marisa L. ; Ford, Michael E. ; Houtz, Jennifer M. ; Karthikeyan, Tharun ; Wadsworth, Curtis ; Lewis, John A. ; Jacobs-Sera, Debbie ; Falbo, Jacob ; Gross, Joseph ; Pannunzio, Nicholas R. ; Brucker, William ; Kumar, Vanaja ; Kandasamy, Jayasankar ; Keenan, Lauren ; Bardarov, Svetsoslav ; Kriakov, Jordan ; Lawrence, Jeffrey G. ; Jacobs, William R. ; Hendrix, Roger W. ; Hatfull, Graham F. / Origins of highly mosaic mycobacteriophage genomes. In: Cell. 2003 ; Vol. 113, No. 2. pp. 171-182.
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