@article{4ec0b4630a434843afa00394f1aa384e,
title = "Origins of highly mosaic mycobacteriophage genomes",
abstract = "Bacteriophages are the most abundant organisms in the biosphere and play major roles in the ecological balance of microbial life. The genomic sequences of ten newly isolated mycobacteriophages suggest that the bacteriophage population as a whole is amazingly diverse and may represent the largest unexplored reservoir of sequence information in the biosphere. Genomic comparison of these mycobacteriophages contributes to our understanding of the mechanisms of viral evolution and provides compelling evidence for the role of illegitimate recombination in horizontal genetic exchange. The promiscuity of these recombination events results in the inclusion of many unexpected genes including those implicated in mycobacterial latency, the cellular and immune responses to mycobacterial infections, and autoimmune diseases such as human lupus. While the role of phages as vehicles of toxin genes is well established, these observations suggest a much broader involvement of phages in bacterial virulence and the host response to bacterial infections.",
author = "Pedulla, {Marisa L.} and Ford, {Michael E.} and Houtz, {Jennifer M.} and Tharun Karthikeyan and Curtis Wadsworth and Lewis, {John A.} and Debbie Jacobs-Sera and Jacob Falbo and Joseph Gross and Pannunzio, {Nicholas R.} and William Brucker and Vanaja Kumar and Jayasankar Kandasamy and Lauren Keenan and Svetsoslav Bardarov and Jordan Kriakov and Lawrence, {Jeffrey G.} and Jacobs, {William R.} and Hendrix, {Roger W.} and Hatfull, {Graham F.}",
note = "Funding Information: This work was supported in part by a grant to the University of Pittsburgh by the Howard Hughes Medical Institute (HHMI) in support of Graham Hatfull under HHMI's Professors program. Support was also provided by grants from NIH to R.W.H. (GM5197508), G.F.H. (AI28927), and W.R.J. (AI26170), from the David and Lucille Packard Foundation (J.G.L.), and the Ellison Medical Foundation (W.R.J.). We thank David Gordon and Phil Green for the Phred, Phrap, and Consed assembly programs and Jeffrey Brodsky and Rick Relyea for helpful comments on the manuscript. We also thank Tom Harper and Aleisha Dobbins for help with the illustrations. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2003",
month = apr,
day = "18",
doi = "10.1016/S0092-8674(03)00233-2",
language = "English (US)",
volume = "113",
pages = "171--182",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}