Optimizing the skeletal muscle biopsy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Knowledge of disorders of skeletal muscle remains of importance for the practicing pathologist. While genetic testing has proved useful in the diagnosis of many patients, especially those with the more common forms of muscular dystrophy, less common genetic myopathies, congenital myopathies, and toxic myopathies, often related to commonly used therapeutic agents such as statins, still require pathological analysis for diagnostic purposes. A contemporary pathologist may expect to be consulted about unusual familial neuromuscular disorders, autoimmune disorders, and drug-induced myopathies, often in the context of patients with multiple medical conditions that complicate the clinical and pathological analysis. A working knowledge of skeletal muscle biopsy and its clinical utility as well as its limitations is therefore important for all pathologists. Each pathologist must decide if they wish to process the biopsy in their own laboratory, or if the specimen should be sent to a reference laboratory for analysis.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages397-410
Number of pages14
Volume1180
ISBN (Print)9781493910496
DOIs
StatePublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1180
ISSN (Print)10643745

Fingerprint

Skeletal Muscle
Muscular Diseases
Biopsy
Myotonia Congenita
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Muscular Dystrophies
Poisons
Genetic Testing
Pathologists
Pharmaceutical Preparations
Therapeutics

Keywords

  • Electron microscopy
  • Histochemistry
  • Muscle biopsy
  • Muscular dystrophy
  • Myopathy
  • Polymyositis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Medicine(all)

Cite this

Weidenheim, K. M. (2014). Optimizing the skeletal muscle biopsy. In Methods in Molecular Biology (Vol. 1180, pp. 397-410). (Methods in Molecular Biology; Vol. 1180). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-1050-2_24

Optimizing the skeletal muscle biopsy. / Weidenheim, Karen M.

Methods in Molecular Biology. Vol. 1180 Humana Press Inc., 2014. p. 397-410 (Methods in Molecular Biology; Vol. 1180).

Research output: Chapter in Book/Report/Conference proceedingChapter

Weidenheim, KM 2014, Optimizing the skeletal muscle biopsy. in Methods in Molecular Biology. vol. 1180, Methods in Molecular Biology, vol. 1180, Humana Press Inc., pp. 397-410. https://doi.org/10.1007/978-1-4939-1050-2_24
Weidenheim KM. Optimizing the skeletal muscle biopsy. In Methods in Molecular Biology. Vol. 1180. Humana Press Inc. 2014. p. 397-410. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-1050-2_24
Weidenheim, Karen M. / Optimizing the skeletal muscle biopsy. Methods in Molecular Biology. Vol. 1180 Humana Press Inc., 2014. pp. 397-410 (Methods in Molecular Biology).
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