Optimizing the skeletal muscle biopsy

Karen M. Weidenheim

Research output: Chapter in Book/Report/Conference proceedingChapter


Knowledge of disorders of skeletal muscle remains of importance for the practicing pathologist. While genetic testing has proved useful in the diagnosis of many patients, especially those with the more common forms of muscular dystrophy, less common genetic myopathies, congenital myopathies, and toxic myopathies, often related to commonly used therapeutic agents such as statins, still require pathological analysis for diagnostic purposes. A contemporary pathologist may expect to be consulted about unusual familial neuromuscular disorders, autoimmune disorders, and drug-induced myopathies, often in the context of patients with multiple medical conditions that complicate the clinical and pathological analysis. A working knowledge of skeletal muscle biopsy and its clinical utility as well as its limitations is therefore important for all pathologists. Each pathologist must decide if they wish to process the biopsy in their own laboratory, or if the specimen should be sent to a reference laboratory for analysis.

Original languageEnglish (US)
Title of host publicationHistopathology
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Number of pages14
ISBN (Print)9781493910496
StatePublished - 2014

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Electron microscopy
  • Histochemistry
  • Muscle biopsy
  • Muscular dystrophy
  • Myopathy
  • Polymyositis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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