Optical tomographic imaging of the hemodynamic response to a breath hold in breast cancer patients

Molly L. Flexman, Michael A. Khalil, Rabah M. Al Abdi, Beatriu Reig, Christopher J. Fong, Dawn Hershman, Elise Desperito, Randall L. Barbour, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Continuous wave optical tomography is non-ionizing, uses endogenous contrast, and can be performed quickly and at low cost which makes it a suitable imaging modality for breast cancer screening. Using multiple wavelengths of light to illuminate the breast at various angles, three-dimensional images of the distribution of chromophores such as oxy- and deoxy-hemoglobin can help identify cancerous tissue. Dynamic optical imaging can provide additional insight into cancer characteristics such as angiogenesis and metabolism. Here we present the first clinical data acquired with our novel digital breast imaging system. This system is based upon a Digital Signal Processor (DSP) architecture that leverages the immediate digitization of acquired analog data to reduce noise and quickly process large amounts of data. Employing this new instrument we have investigated the dynamic changes due to a breath hold and its potential for use in breast cancer screening. Over the course of a breath hold, images have been collected simultaneously from both breasts at a rate of 1.7 frames per second with 32 sources and 64 detectors per breast and four wavelengths of light at 765, 805, 827, and 905nm. Initial results involving one healthy volunteer and one breast cancer patient support the potential use of dynamic imaging for breast cancer detection.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7896
DOIs
StatePublished - 2011
Externally publishedYes
EventOptical Tomography and Spectroscopy of Tissue IX - San Francisco, CA, United States
Duration: Jan 23 2011Jan 26 2011

Other

OtherOptical Tomography and Spectroscopy of Tissue IX
CountryUnited States
CitySan Francisco, CA
Period1/23/111/26/11

Fingerprint

hemodynamic responses
Optical Imaging
Hemodynamics
breast
Breast
cancer
Hemoglobin
Breast Neoplasms
Imaging techniques
Screening
Hemoglobins
Early Detection of Cancer
Wavelength
Optical tomography
Analog to digital conversion
Optical Tomography
Digital signal processors
Chromophores
Light
Metabolism

Keywords

  • breast cancer
  • breath hold
  • digital signal processing
  • dynamic imaging
  • Optical tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Flexman, M. L., Khalil, M. A., Al Abdi, R. M., Reig, B., Fong, C. J., Hershman, D., ... Hielscher, A. H. (2011). Optical tomographic imaging of the hemodynamic response to a breath hold in breast cancer patients. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7896). [78962J] https://doi.org/10.1117/12.875461

Optical tomographic imaging of the hemodynamic response to a breath hold in breast cancer patients. / Flexman, Molly L.; Khalil, Michael A.; Al Abdi, Rabah M.; Reig, Beatriu; Fong, Christopher J.; Hershman, Dawn; Desperito, Elise; Barbour, Randall L.; Hielscher, Andreas H.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7896 2011. 78962J.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Flexman, ML, Khalil, MA, Al Abdi, RM, Reig, B, Fong, CJ, Hershman, D, Desperito, E, Barbour, RL & Hielscher, AH 2011, Optical tomographic imaging of the hemodynamic response to a breath hold in breast cancer patients. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7896, 78962J, Optical Tomography and Spectroscopy of Tissue IX, San Francisco, CA, United States, 1/23/11. https://doi.org/10.1117/12.875461
Flexman ML, Khalil MA, Al Abdi RM, Reig B, Fong CJ, Hershman D et al. Optical tomographic imaging of the hemodynamic response to a breath hold in breast cancer patients. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7896. 2011. 78962J https://doi.org/10.1117/12.875461
Flexman, Molly L. ; Khalil, Michael A. ; Al Abdi, Rabah M. ; Reig, Beatriu ; Fong, Christopher J. ; Hershman, Dawn ; Desperito, Elise ; Barbour, Randall L. ; Hielscher, Andreas H. / Optical tomographic imaging of the hemodynamic response to a breath hold in breast cancer patients. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7896 2011.
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