Open trial of intravenous clomipramine in five treatment-refractory patients with obsessive-compulsive disorder

B. A. Fallon, R. Campeas, F. R. Schneier, E. Hollander, J. Feerick, J. Hatterer, D. Goetz, S. Davies, M. R. Liebowitz

Research output: Contribution to journalArticle

31 Scopus citations


In a preliminary trial, five oral-clomipramine-refractory patients with obsessive-compulsive disorder (OCD) were treated openly with 14 intravenous clomipramine infusions each. Using standardized assessments, three patients were rated as much improved, one as unchanged, and one as minimally improved. Statistically significant improvements were noted on both the Yale-Brown Obsessive Compulsive Scale and the NIMH Global OCD scores. No patient discontinued treatment because of side effects. Although the results are provocative in that three of five patients were much improved at the end of the protocol, conclusions about preferential efficacy for the intravenous route must await a placebo-controlled trial.

Original languageEnglish (US)
Pages (from-to)70-75
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
Publication statusPublished - Jan 1 1992
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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