Only scratching the cell surface

Extracellular signals in cerebrum development

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Numerous roles have been identified for extracellular signals such as Fibroblast Growth Factors (FGFs), Transforming Growth Factor-βs (TGFβs), Wingless-Int proteins (WNTs), and Sonic Hedgehog (SHH) in assigning fates to cells during development of the cerebrum. However, several fundamental questions remain largely unexplored. First, how does the same extracellular signal instruct precursor cells in different locations or at different stages to adopt distinct fates? And second, how does a precursor cell integrate multiple signals to adopt a specific fate? Answers to these questions require knowing the mechanisms that underlie each cell type's competence to respond to certain extracellular signals. This brief review provides illustrative examples of potential mechanisms that begin to bridge the gap between cell surface and cell fate during cerebrum development.

Original languageEnglish (US)
Pages (from-to)470-474
Number of pages5
JournalCurrent Opinion in Genetics and Development
Volume23
Issue number4
DOIs
StatePublished - Aug 2013

Fingerprint

Cerebrum
Hedgehog Proteins
Fibroblast Growth Factors
Transforming Growth Factors
Mental Competency

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Medicine(all)

Cite this

Only scratching the cell surface : Extracellular signals in cerebrum development. / Hebert, Jean M.

In: Current Opinion in Genetics and Development, Vol. 23, No. 4, 08.2013, p. 470-474.

Research output: Contribution to journalArticle

@article{3aa9d561932e46d4a8092438d2b0f943,
title = "Only scratching the cell surface: Extracellular signals in cerebrum development",
abstract = "Numerous roles have been identified for extracellular signals such as Fibroblast Growth Factors (FGFs), Transforming Growth Factor-βs (TGFβs), Wingless-Int proteins (WNTs), and Sonic Hedgehog (SHH) in assigning fates to cells during development of the cerebrum. However, several fundamental questions remain largely unexplored. First, how does the same extracellular signal instruct precursor cells in different locations or at different stages to adopt distinct fates? And second, how does a precursor cell integrate multiple signals to adopt a specific fate? Answers to these questions require knowing the mechanisms that underlie each cell type's competence to respond to certain extracellular signals. This brief review provides illustrative examples of potential mechanisms that begin to bridge the gap between cell surface and cell fate during cerebrum development.",
author = "Hebert, {Jean M.}",
year = "2013",
month = "8",
doi = "10.1016/j.gde.2013.04.004",
language = "English (US)",
volume = "23",
pages = "470--474",
journal = "Current Opinion in Genetics and Development",
issn = "0959-437X",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Only scratching the cell surface

T2 - Extracellular signals in cerebrum development

AU - Hebert, Jean M.

PY - 2013/8

Y1 - 2013/8

N2 - Numerous roles have been identified for extracellular signals such as Fibroblast Growth Factors (FGFs), Transforming Growth Factor-βs (TGFβs), Wingless-Int proteins (WNTs), and Sonic Hedgehog (SHH) in assigning fates to cells during development of the cerebrum. However, several fundamental questions remain largely unexplored. First, how does the same extracellular signal instruct precursor cells in different locations or at different stages to adopt distinct fates? And second, how does a precursor cell integrate multiple signals to adopt a specific fate? Answers to these questions require knowing the mechanisms that underlie each cell type's competence to respond to certain extracellular signals. This brief review provides illustrative examples of potential mechanisms that begin to bridge the gap between cell surface and cell fate during cerebrum development.

AB - Numerous roles have been identified for extracellular signals such as Fibroblast Growth Factors (FGFs), Transforming Growth Factor-βs (TGFβs), Wingless-Int proteins (WNTs), and Sonic Hedgehog (SHH) in assigning fates to cells during development of the cerebrum. However, several fundamental questions remain largely unexplored. First, how does the same extracellular signal instruct precursor cells in different locations or at different stages to adopt distinct fates? And second, how does a precursor cell integrate multiple signals to adopt a specific fate? Answers to these questions require knowing the mechanisms that underlie each cell type's competence to respond to certain extracellular signals. This brief review provides illustrative examples of potential mechanisms that begin to bridge the gap between cell surface and cell fate during cerebrum development.

UR - http://www.scopus.com/inward/record.url?scp=84883460673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883460673&partnerID=8YFLogxK

U2 - 10.1016/j.gde.2013.04.004

DO - 10.1016/j.gde.2013.04.004

M3 - Article

VL - 23

SP - 470

EP - 474

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

SN - 0959-437X

IS - 4

ER -