Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms

D. Smotkin, H. Prokoph, F. O. Wettstein

Research output: Contribution to journalArticle

202 Scopus citations

Abstract

A new promoter located within E6 was mapped in human papillomavirus type 6b (HPV6b)- and HPV11-containing benign genital condylomata (genital warts). The RNA transcribed from this promoter represented the major RNA species colinear with open reading frames E6 and E7 and can encode the E7 protein. No equivalent promoter was active in HPV16-containing cancers and cancer-derived cell lines. In those, the major transcripts contained one of two different introns within E6 and the RNAs could encode two different E6* proteins and E7.

Original languageEnglish (US)
Pages (from-to)1441-1447
Number of pages7
JournalJournal of virology
Volume63
Issue number3
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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