On the basic mechanisms of infantile spasms

John W. Swann, Solomon L. Moshe

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The neurobiologic basis for infantile spasms has long been debated but with little resolution. The very recent development of several animal models of this disorder should provide a paradigm shift in our understanding of this disorder. This chapter outlines unresolved questions and suggests experimental approaches to answering them. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at).

Original languageEnglish (US)
Pages (from-to)27
Number of pages1
Issue numberSUPPL. 5
StatePublished - Dec 2010


  • Animal models
  • Brain development
  • Cognitive disabilities
  • Electrodecremental response
  • Epilepsy
  • Hypsarrhythmia
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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