Office and Field Diagnosis of Neurotoxic Disease

Joseph C. Arezzo, Herbert H. Schaumburg

Research output: Contribution to journalArticle

Abstract

Accurate diagnosis of neurotoxic disease requires a fundamental knowledge of the principles of neurology, epidemiology, and toxicology. The cardinal features of the office evaluation of this condition are the detailed history and meticulous clinical examination of an individual; the examination focuses on detecting naturally occurring disease that may account for or mask the principal signs and symptoms. Specialized diagnostic tests can provide an important complement to the office evaluation but are often nonspecific for neurotoxic disease. Field assessment, in contrast, rarely utilizes detailed examinations and depends heavily on quantitative screening tools, such as questionaires, tremor analysis, computer-assisted neurobehavioral tests, and quantitative sensory tests. Field studies generally have two goals: the identification of population cohort differences and the detection of individual members of a group that differ from a population or the expected norm. No single procedure is optimal for all field studies; rather, the methods and analyses should be tailored for the population and toxin under study.

Original languageEnglish (US)
Pages (from-to)311-319
Number of pages9
JournalInternational Journal of Toxicology
Volume8
Issue number2
DOIs
StatePublished - 1989

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Population
Epidemiology
Neurology
Tremor
Masks
Routine Diagnostic Tests
Individuality
Toxicology
Signs and Symptoms
Screening
History

ASJC Scopus subject areas

  • Toxicology

Cite this

Office and Field Diagnosis of Neurotoxic Disease. / Arezzo, Joseph C.; Schaumburg, Herbert H.

In: International Journal of Toxicology, Vol. 8, No. 2, 1989, p. 311-319.

Research output: Contribution to journalArticle

Arezzo, Joseph C. ; Schaumburg, Herbert H. / Office and Field Diagnosis of Neurotoxic Disease. In: International Journal of Toxicology. 1989 ; Vol. 8, No. 2. pp. 311-319.
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