Abstract
The authors describe serial evaluations of a 44-year-old man who became cognitively impaired during a 6-year period of repeated exposure to high levels of methyl isobutyl ketone (MIBK). Neuropsychological tests administered six times over 10 years demonstrated a stable pattern of cognitive impairment. Dynamic imaging studies suggested persistent CNS dysfunction. The authors conclude that chronic, high-level, occupational MIBK exposure can cause a persistent cognitive syndrome best explained by impaired working memory.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1853-1855 |
| Number of pages | 3 |
| Journal | Neurology |
| Volume | 54 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 9 2000 |
Keywords
- Cognitive dysfunction
- Methyl isobutyl ketone
- Occupational exposure
- Working memory
ASJC Scopus subject areas
- Clinical Neurology
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Grober, E., & Schaumburg, H. H. (2000). Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory. Neurology, 54(9), 1853-1855. https://doi.org/10.1212/WNL.54.9.1853