Abstract
The authors describe serial evaluations of a 44-year-old man who became cognitively impaired during a 6-year period of repeated exposure to high levels of methyl isobutyl ketone (MIBK). Neuropsychological tests administered six times over 10 years demonstrated a stable pattern of cognitive impairment. Dynamic imaging studies suggested persistent CNS dysfunction. The authors conclude that chronic, high-level, occupational MIBK exposure can cause a persistent cognitive syndrome best explained by impaired working memory.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1853-1855 |
| Number of pages | 3 |
| Journal | Neurology |
| Volume | 54 |
| Issue number | 9 |
| State | Published - May 9 2000 |
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Keywords
- Cognitive dysfunction
- Methyl isobutyl ketone
- Occupational exposure
- Working memory
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory. / Grober, Ellen; Schaumburg, Herbert H.
In: Neurology, Vol. 54, No. 9, 09.05.2000, p. 1853-1855.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory
AU - Grober, Ellen
AU - Schaumburg, Herbert H.
PY - 2000/5/9
Y1 - 2000/5/9
N2 - The authors describe serial evaluations of a 44-year-old man who became cognitively impaired during a 6-year period of repeated exposure to high levels of methyl isobutyl ketone (MIBK). Neuropsychological tests administered six times over 10 years demonstrated a stable pattern of cognitive impairment. Dynamic imaging studies suggested persistent CNS dysfunction. The authors conclude that chronic, high-level, occupational MIBK exposure can cause a persistent cognitive syndrome best explained by impaired working memory.
AB - The authors describe serial evaluations of a 44-year-old man who became cognitively impaired during a 6-year period of repeated exposure to high levels of methyl isobutyl ketone (MIBK). Neuropsychological tests administered six times over 10 years demonstrated a stable pattern of cognitive impairment. Dynamic imaging studies suggested persistent CNS dysfunction. The authors conclude that chronic, high-level, occupational MIBK exposure can cause a persistent cognitive syndrome best explained by impaired working memory.
KW - Cognitive dysfunction
KW - Methyl isobutyl ketone
KW - Occupational exposure
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=0034624933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034624933&partnerID=8YFLogxK
M3 - Article
C2 - 10802798
AN - SCOPUS:0034624933
VL - 54
SP - 1853
EP - 1855
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 9
ER -