Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory

Ellen Grober, Herbert H. Schaumburg

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The authors describe serial evaluations of a 44-year-old man who became cognitively impaired during a 6-year period of repeated exposure to high levels of methyl isobutyl ketone (MIBK). Neuropsychological tests administered six times over 10 years demonstrated a stable pattern of cognitive impairment. Dynamic imaging studies suggested persistent CNS dysfunction. The authors conclude that chronic, high-level, occupational MIBK exposure can cause a persistent cognitive syndrome best explained by impaired working memory.

Original languageEnglish (US)
Pages (from-to)1853-1855
Number of pages3
JournalNeurology
Volume54
Issue number9
StatePublished - May 9 2000

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Occupational Exposure
Short-Term Memory
Neuropsychological Tests
methyl isobutyl ketone
Cognitive Dysfunction

Keywords

  • Cognitive dysfunction
  • Methyl isobutyl ketone
  • Occupational exposure
  • Working memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory. / Grober, Ellen; Schaumburg, Herbert H.

In: Neurology, Vol. 54, No. 9, 09.05.2000, p. 1853-1855.

Research output: Contribution to journalArticle

Grober, E & Schaumburg, HH 2000, 'Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory', Neurology, vol. 54, no. 9, pp. 1853-1855.
Grober, Ellen ; Schaumburg, Herbert H. / Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory. In: Neurology. 2000 ; Vol. 54, No. 9. pp. 1853-1855.
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