Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory

Ellen Grober; Herbert H. Schaumburg

doi:10.1212/WNL.54.9.1853

Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory

Ellen Grober, Herbert H. Schaumburg

Neurology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The authors describe serial evaluations of a 44-year-old man who became cognitively impaired during a 6-year period of repeated exposure to high levels of methyl isobutyl ketone (MIBK). Neuropsychological tests administered six times over 10 years demonstrated a stable pattern of cognitive impairment. Dynamic imaging studies suggested persistent CNS dysfunction. The authors conclude that chronic, high-level, occupational MIBK exposure can cause a persistent cognitive syndrome best explained by impaired working memory.

Original language	English (US)
Pages (from-to)	1853-1855
Number of pages	3
Journal	Neurology
Volume	54
Issue number	9
DOIs	https://doi.org/10.1212/WNL.54.9.1853
State	Published - May 9 2000

Keywords

Cognitive dysfunction
Methyl isobutyl ketone
Occupational exposure
Working memory

ASJC Scopus subject areas

Clinical Neurology

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