Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory

Ellen Grober, Herbert H. Schaumburg

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The authors describe serial evaluations of a 44-year-old man who became cognitively impaired during a 6-year period of repeated exposure to high levels of methyl isobutyl ketone (MIBK). Neuropsychological tests administered six times over 10 years demonstrated a stable pattern of cognitive impairment. Dynamic imaging studies suggested persistent CNS dysfunction. The authors conclude that chronic, high-level, occupational MIBK exposure can cause a persistent cognitive syndrome best explained by impaired working memory.

Original languageEnglish (US)
Pages (from-to)1853-1855
Number of pages3
JournalNeurology
Volume54
Issue number9
DOIs
StatePublished - May 9 2000

Keywords

  • Cognitive dysfunction
  • Methyl isobutyl ketone
  • Occupational exposure
  • Working memory

ASJC Scopus subject areas

  • Clinical Neurology

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