Obstructive sleep apnea and acute myocardial infarction severity

Ischemic preconditioning?

Neomi Shah, Susan Redline, H. Klar Yaggi, Richard Wu, C. George Zhao, Robert J Ostfeld, Mark A. Menegus, Daniel Tracy, Elizabeth Brush, David W. Appel, Robert C. Kaplan

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Background: Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia (IH). In animal models, IH has been shown to protect the myocardium during periods of ischemia by reducing infarct size. However, this phenomenon of "ischemic preconditioning" has not been investigated among OSA patients with acute myocardial infarction (MI). This study investigates the role of OSA on MI severity as measured by cardiac enzymes, specifically troponin-T, among patients with an acute MI. Methods: This is an observational cohort study of patients ≥18 years of age who were hospitalized with an acute MI. Each participant underwent portable sleep monitoring (Apnea Link Plus); OSA was defined as an apnea-hypopnea index ≥5/h. Multivariable regression analysis was conducted to assess the relationship between OSA and highly sensitive troponin-T levels. Results: In our entire cohort of acute MI patients (n = 136), 77 % of the sample had evidence of sleep disordered breathing, with 35 % of the sample having OSA (i.e., an AHI >5). Higher AHI was associated with lower peak troponin-T levels in partially adjusted models (β = -0.0320, p = 0.0074, adjusted for age, gender, and race) and fully adjusted models (β = -0.0322, p = 0.0085) (additionally adjusted for smoking, hypertension, hyperlipidemia, body mass index, history of prior cardiovascular or cerebrovascular disease, diabetes and baseline admission creatinine levels). The mean value of the log-transformed peak troponin-T variable was used to dichotomize the outcome variable. In both partially (OR 0.949, CI 0.905-0.995, p = 0.03) and fully adjusted (OR 0.918, CI 0.856-0.984, p = 0.0151) logistic regression models, the OR for AHI suggests a protective effect on high troponin-T level. Conclusions: Our study demonstrates that patients with OSA have less severe cardiac injury during an acute non-fatal MI when compared to patients without OSA. This may suggest a cardioprotective role of sleep apnea during acute MI via ischemic preconditioning.

Original languageEnglish (US)
Pages (from-to)819-826
Number of pages8
JournalSleep and Breathing
Volume17
Issue number2
DOIs
StatePublished - May 2013

Fingerprint

Ischemic Preconditioning
Obstructive Sleep Apnea
Troponin T
Myocardial Infarction
Sleep Apnea Syndromes
Logistic Models
Cerebrovascular Disorders
Polysomnography
Apnea
Hyperlipidemias
Observational Studies
Creatinine
Myocardium
Body Mass Index
Cohort Studies
Cardiovascular Diseases
Ischemia
Animal Models
Smoking
Regression Analysis

Keywords

  • Cardiac enzymes
  • Intermittent hypoxemia
  • Ischemic preconditioning
  • Myocardial infarction
  • Obstructive sleep apnea

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology

Cite this

Obstructive sleep apnea and acute myocardial infarction severity : Ischemic preconditioning? / Shah, Neomi; Redline, Susan; Yaggi, H. Klar; Wu, Richard; Zhao, C. George; Ostfeld, Robert J; Menegus, Mark A.; Tracy, Daniel; Brush, Elizabeth; Appel, David W.; Kaplan, Robert C.

In: Sleep and Breathing, Vol. 17, No. 2, 05.2013, p. 819-826.

Research output: Contribution to journalArticle

Shah, Neomi ; Redline, Susan ; Yaggi, H. Klar ; Wu, Richard ; Zhao, C. George ; Ostfeld, Robert J ; Menegus, Mark A. ; Tracy, Daniel ; Brush, Elizabeth ; Appel, David W. ; Kaplan, Robert C. / Obstructive sleep apnea and acute myocardial infarction severity : Ischemic preconditioning?. In: Sleep and Breathing. 2013 ; Vol. 17, No. 2. pp. 819-826.
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abstract = "Background: Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia (IH). In animal models, IH has been shown to protect the myocardium during periods of ischemia by reducing infarct size. However, this phenomenon of {"}ischemic preconditioning{"} has not been investigated among OSA patients with acute myocardial infarction (MI). This study investigates the role of OSA on MI severity as measured by cardiac enzymes, specifically troponin-T, among patients with an acute MI. Methods: This is an observational cohort study of patients ≥18 years of age who were hospitalized with an acute MI. Each participant underwent portable sleep monitoring (Apnea Link Plus); OSA was defined as an apnea-hypopnea index ≥5/h. Multivariable regression analysis was conducted to assess the relationship between OSA and highly sensitive troponin-T levels. Results: In our entire cohort of acute MI patients (n = 136), 77 {\%} of the sample had evidence of sleep disordered breathing, with 35 {\%} of the sample having OSA (i.e., an AHI >5). Higher AHI was associated with lower peak troponin-T levels in partially adjusted models (β = -0.0320, p = 0.0074, adjusted for age, gender, and race) and fully adjusted models (β = -0.0322, p = 0.0085) (additionally adjusted for smoking, hypertension, hyperlipidemia, body mass index, history of prior cardiovascular or cerebrovascular disease, diabetes and baseline admission creatinine levels). The mean value of the log-transformed peak troponin-T variable was used to dichotomize the outcome variable. In both partially (OR 0.949, CI 0.905-0.995, p = 0.03) and fully adjusted (OR 0.918, CI 0.856-0.984, p = 0.0151) logistic regression models, the OR for AHI suggests a protective effect on high troponin-T level. Conclusions: Our study demonstrates that patients with OSA have less severe cardiac injury during an acute non-fatal MI when compared to patients without OSA. This may suggest a cardioprotective role of sleep apnea during acute MI via ischemic preconditioning.",
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AU - Wu, Richard

AU - Zhao, C. George

AU - Ostfeld, Robert J

AU - Menegus, Mark A.

AU - Tracy, Daniel

AU - Brush, Elizabeth

AU - Appel, David W.

AU - Kaplan, Robert C.

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N2 - Background: Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia (IH). In animal models, IH has been shown to protect the myocardium during periods of ischemia by reducing infarct size. However, this phenomenon of "ischemic preconditioning" has not been investigated among OSA patients with acute myocardial infarction (MI). This study investigates the role of OSA on MI severity as measured by cardiac enzymes, specifically troponin-T, among patients with an acute MI. Methods: This is an observational cohort study of patients ≥18 years of age who were hospitalized with an acute MI. Each participant underwent portable sleep monitoring (Apnea Link Plus); OSA was defined as an apnea-hypopnea index ≥5/h. Multivariable regression analysis was conducted to assess the relationship between OSA and highly sensitive troponin-T levels. Results: In our entire cohort of acute MI patients (n = 136), 77 % of the sample had evidence of sleep disordered breathing, with 35 % of the sample having OSA (i.e., an AHI >5). Higher AHI was associated with lower peak troponin-T levels in partially adjusted models (β = -0.0320, p = 0.0074, adjusted for age, gender, and race) and fully adjusted models (β = -0.0322, p = 0.0085) (additionally adjusted for smoking, hypertension, hyperlipidemia, body mass index, history of prior cardiovascular or cerebrovascular disease, diabetes and baseline admission creatinine levels). The mean value of the log-transformed peak troponin-T variable was used to dichotomize the outcome variable. In both partially (OR 0.949, CI 0.905-0.995, p = 0.03) and fully adjusted (OR 0.918, CI 0.856-0.984, p = 0.0151) logistic regression models, the OR for AHI suggests a protective effect on high troponin-T level. Conclusions: Our study demonstrates that patients with OSA have less severe cardiac injury during an acute non-fatal MI when compared to patients without OSA. This may suggest a cardioprotective role of sleep apnea during acute MI via ischemic preconditioning.

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