Observations on the development of the weaver mouse cerebellum

Asao Hirano, Herbert M. Dembitzer

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The cerebellar cortices of young weaver mice were examined by electron microscopy and compared with those of normal littcrmatcs. Unattached dendritic spines arising from Purkinjc cells, very much like those previously described in the adult weaver, were found by the eleventh day after birth. Granule cell degeneration was seen but no examples of degeneration of presynaptic structures could be detected. Unlike cither the adult weaver or the developing normal mouse, symmetrical junctions between dendritic spines were present, as were asymmetrical junctions between Purkinjc cell dendritic spines and nonspc-cialized regions of the surface of external granule cell soma. The mechanism of formation of the unattached spines is discussed.

Original languageEnglish (US)
Pages (from-to)354-364
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume33
Issue number3
StatePublished - 1974

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Neurologic Mutant Mice
Dendritic Spines
Cerebellum
Cerebellar Cortex
Carisoprodol
Electron Microscopy
Spine
Parturition

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Observations on the development of the weaver mouse cerebellum. / Hirano, Asao; Dembitzer, Herbert M.

In: Journal of Neuropathology and Experimental Neurology, Vol. 33, No. 3, 1974, p. 354-364.

Research output: Contribution to journalArticle

Hirano, Asao ; Dembitzer, Herbert M. / Observations on the development of the weaver mouse cerebellum. In: Journal of Neuropathology and Experimental Neurology. 1974 ; Vol. 33, No. 3. pp. 354-364.
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