Objective response of multiple myeloma to cyclosporin a

Peter H. Wiernik, Janice P. Dutcher, Andrea N. Leaf, Zenghua Liao, Elisabeth Paietta, David L. Rosenstreich

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Two patients with advanced multiple myeloma were treated with oral low-dose cyclosporin A, one without other therapy and one in conjunction with chemotherapy to which the patient had been previously unresponsive. Both patients had objective laboratory and clinical responses. In the patient treated with cyclosporin A alone, decreasing serum IL-6 and beta-2-microglobulin levels fell as the clinical response evolved. Cyclosporin A deserves further evaluation in the therapy of multiple myeloma.

Original languageEnglish (US)
Pages (from-to)167-170
Number of pages4
JournalLeukemia and Lymphoma
Volume16
Issue number1-2
DOIs
StatePublished - Jan 1 1994

Keywords

  • Cyclosporin therapy
  • Myeloma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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