Obesity and right ventricular structure and function

The MESA-right ventricle study

Harjit Chahal, Robyn L. McClelland, Harikrishna Tandri, Aditya Jain, Evrim B. Turkbey, W. Gregory Hundley, R. Graham Barr, Jorge Kizer, João A C Lima, David A. Bluemke, Steven M. Kawut

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: The relationship between obesity and right ventricular (RV) morphology is not well studied. We aimed to determine the association between obesity and RV structure and function in a large multiethnic population-based cohort. Methods: The MESA-Right Ventricle Study measured RV mass and volumes by cardiac MRI in participants aged 45 to 84 years without clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis (MESA). Participants were divided into three categories based on BMI: lean (≤24.9 kg/m 2), overweight (25-29.9 kg/m 2), and obese (≥30 kg/m 2). Results: The study sample included 4,127 participants. After adjustment for demographics, height, education, and cardiovascular risk factors, overweight and obese participants had greater RV mass (6% and 9% greater, respectively), larger RV end-diastolic volume (8% and 18% greater, respectively), larger RV stroke volume (7% and 16% greater, respectively), and lower RV ejection fraction (≥1% lower) than lean participants (all P<.001). These findings persisted after adjusting for the respective left ventricular (LV) parameters. Conclusions: Overweight and obesity were independently associated with differences in RV morphology even after adjustment for the respective LV measure. This association could be explained by increased RV afterload, increased blood volume, hormonal effects, or direct obesity-related myocardial effects.

Original languageEnglish (US)
Pages (from-to)388-395
Number of pages8
JournalChest
Volume141
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

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Right Ventricular Function
Heart Ventricles
Atherosclerosis
Obesity
Stroke Volume
Cardiac Volume
Blood Volume
Cardiovascular Diseases
Demography
Education
Population

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Chahal, H., McClelland, R. L., Tandri, H., Jain, A., Turkbey, E. B., Hundley, W. G., ... Kawut, S. M. (2012). Obesity and right ventricular structure and function: The MESA-right ventricle study. Chest, 141(2), 388-395. https://doi.org/10.1378/chest.11-0172

Obesity and right ventricular structure and function : The MESA-right ventricle study. / Chahal, Harjit; McClelland, Robyn L.; Tandri, Harikrishna; Jain, Aditya; Turkbey, Evrim B.; Hundley, W. Gregory; Barr, R. Graham; Kizer, Jorge; Lima, João A C; Bluemke, David A.; Kawut, Steven M.

In: Chest, Vol. 141, No. 2, 02.2012, p. 388-395.

Research output: Contribution to journalArticle

Chahal, H, McClelland, RL, Tandri, H, Jain, A, Turkbey, EB, Hundley, WG, Barr, RG, Kizer, J, Lima, JAC, Bluemke, DA & Kawut, SM 2012, 'Obesity and right ventricular structure and function: The MESA-right ventricle study', Chest, vol. 141, no. 2, pp. 388-395. https://doi.org/10.1378/chest.11-0172
Chahal H, McClelland RL, Tandri H, Jain A, Turkbey EB, Hundley WG et al. Obesity and right ventricular structure and function: The MESA-right ventricle study. Chest. 2012 Feb;141(2):388-395. https://doi.org/10.1378/chest.11-0172
Chahal, Harjit ; McClelland, Robyn L. ; Tandri, Harikrishna ; Jain, Aditya ; Turkbey, Evrim B. ; Hundley, W. Gregory ; Barr, R. Graham ; Kizer, Jorge ; Lima, João A C ; Bluemke, David A. ; Kawut, Steven M. / Obesity and right ventricular structure and function : The MESA-right ventricle study. In: Chest. 2012 ; Vol. 141, No. 2. pp. 388-395.
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AU - Jain, Aditya

AU - Turkbey, Evrim B.

AU - Hundley, W. Gregory

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