Nucteotide sequences of bovine αS1- and x-casein cDNAs

A. F. Stewart, Ian M. Willis, A. F. Mackinlay

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

The nucleotide sequences corresponding to bovine αS1- and k-casein mRNAs are presented. An unusual αS1-casein cDNA has been characterised whose 5′ end commences upstream from its putative TATA box. The αS1- casein mRNA is compared to rat αS1-casein mRNA and two components of divergence are identified. Firstly, the two sequences have diverged at a high point mutation rate and the rate of amino acid replacement by this mechanism is at least as great as the rate of divergence of any other part of the mRNAs. Secondly, the protein coding sequence has been subjected to several insertion/deletion events, one of which may be an example of exon shuffling. The x-casein mRNA sequence verifies the proposition that it has arisen from a different ancestral gene to the other caseins.

Original languageEnglish (US)
Pages (from-to)3895-3907
Number of pages13
JournalNucleic Acids Research
Volume12
Issue number9
DOIs
StatePublished - May 11 1984
Externally publishedYes

Fingerprint

Casein
Caseins
CDNA
Messenger RNA
Complementary DNA
Divergence
TATA Box
Proposition
Deletion
Insertion
Replacement
Mutation Rate
Amino Acids
Nucleotides
Point Mutation
Mutation
Coding
cDNA
Bovine
Amino acids

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

Nucteotide sequences of bovine αS1- and x-casein cDNAs. / Stewart, A. F.; Willis, Ian M.; Mackinlay, A. F.

In: Nucleic Acids Research, Vol. 12, No. 9, 11.05.1984, p. 3895-3907.

Research output: Contribution to journalArticle

Stewart, A. F. ; Willis, Ian M. ; Mackinlay, A. F. / Nucteotide sequences of bovine αS1- and x-casein cDNAs. In: Nucleic Acids Research. 1984 ; Vol. 12, No. 9. pp. 3895-3907.
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