Nucleus raphe dorsalis in Alzheimer's disease

Neurofibrillary tangles and loss of large neurons

T. Yamamoto, A. Hirano

Research output: Contribution to journalArticle

270 Citations (Scopus)

Abstract

Diffuse serotonergic fibers are presumed to project to the telencephalon from the nucleus raphe dorsalis (NRD) of the midbrain, in a manner similar to the cholinergic projections from the nucleus basalis of Meynert (nbM) to the cerebral cortex. Neuropathological changes in both of these nuclei have been reported in Alzheimer's disease (AD). Although many morphometric studies of the nbM in AD have been documented, only one such study of the NRD has been conducted so far; it demonstrated a sixfold increase in neurofibrillary tangles in AD but no statistically significant difference in the number of neurons in patients with AD and age-matched controls. A study of the NRD utilizing different stains and wider anatomical boundaries is detailed in this report of 5 patients with AD and 7 age-matched controls. In AD the NRD showed 39 times more neurofibrillary tangles and the number and cell density of large neurons were reduced to 23% and 28%, respectively, of those in the controls. A small number of senile plaques were found in the NRD in all patients with AD but none were found in the controls.

Original languageEnglish (US)
Pages (from-to)573-577
Number of pages5
JournalAnnals of Neurology
Volume17
Issue number6
StatePublished - 1985

Fingerprint

Neurofibrillary Tangles
Alzheimer Disease
Neurons
Basal Nucleus of Meynert
Telencephalon
Amyloid Plaques
Mesencephalon
Cerebral Cortex
Cholinergic Agents
Dorsal Raphe Nucleus
Coloring Agents
Cell Count

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nucleus raphe dorsalis in Alzheimer's disease : Neurofibrillary tangles and loss of large neurons. / Yamamoto, T.; Hirano, A.

In: Annals of Neurology, Vol. 17, No. 6, 1985, p. 573-577.

Research output: Contribution to journalArticle

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