Nucleoside-analog resistance mutations in HIV-1 reverse transcriptase and their influence on polymerase fidelity and viral mutation rates

Medicine & Life Sciences

• Human immunodeficiency virus 1 reverse transcriptase 100%
• Mutation Rate 77%
• Nucleosides 77%
• HIV-1 63%
• RNA-Directed DNA Polymerase 42%
• Mutation 40%
• Biochemistry 32%
• Viruses 24%
• Viral Genome 20%
• Highly Active Antiretroviral Therapy 20%
• Drug Resistance 16%
• Pharmaceutical Preparations 15%
• Enzymes 9%

Chemical Compounds

• Nucleoside Analogue 88%
• Mutation 61%
• Resistance 45%
• Biochemistry 33%
• Antiretroviral 25%
• Drug 19%