Nuclear export dynamics of RNA-"protein complexes

David Grünwald, Robert H. Singer, Michael Rout

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The central dogma of molecular biology-" DNA makes RNA makes proteins-" is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.

Original languageEnglish (US)
Pages (from-to)333-341
Number of pages9
JournalNature
Volume475
Issue number7356
DOIs
StatePublished - Jul 21 2011

Fingerprint

Cell Nucleus Active Transport
Nuclear Envelope
RNA
Nuclear Pore
Architectural Accessibility
Proteins
Eukaryota
Molecular Biology
Genome
DNA

ASJC Scopus subject areas

  • General

Cite this

Nuclear export dynamics of RNA-"protein complexes. / Grünwald, David; Singer, Robert H.; Rout, Michael.

In: Nature, Vol. 475, No. 7356, 21.07.2011, p. 333-341.

Research output: Contribution to journalArticle

Grünwald, D, Singer, RH & Rout, M 2011, 'Nuclear export dynamics of RNA-"protein complexes', Nature, vol. 475, no. 7356, pp. 333-341. https://doi.org/10.1038/nature10318
Grünwald, David ; Singer, Robert H. ; Rout, Michael. / Nuclear export dynamics of RNA-"protein complexes. In: Nature. 2011 ; Vol. 475, No. 7356. pp. 333-341.
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