Nuclear export dynamics of RNA-"protein complexes

David Grünwald, Robert H. Singer, Michael Rout

Research output: Contribution to journalReview article

116 Scopus citations

Abstract

The central dogma of molecular biology-" DNA makes RNA makes proteins-" is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.

Original languageEnglish (US)
Pages (from-to)333-341
Number of pages9
JournalNature
Volume475
Issue number7356
DOIs
StatePublished - Jul 21 2011

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ASJC Scopus subject areas

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