Novel mouse models for understanding HIV-1 pathogenesis

Aviva Joseph, Kaori Sango, Harris Goldstein

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Small animal models in which in vivo HIV-1 infection, pathogenesis, and immune responses can be studied would permit both basic research on the biology of the disease, as well as a system to rapidly screen developmental therapeutics and/or vaccines. To date, the most widely-used models have been the severe combined immunodeficient (SCID)-hu (also known as the thy/liv SCID-hu) and the huPBL-SCID mouse models. Recently three new models have emerged, i.e., the intrasplenic huPBL/SPL-SCID model, the NOD/SCID/IL2Rγnull mouse model, and the $Rag2-/-γc-/- mouse model. Details on the construction, maintenance and HIV-1 infection of these models are discussed.

Original languageEnglish (US)
Title of host publicationHIV Protocols
EditorsVinayaka R. Prasad, Ganjam V. Kalpana
Pages311-327
Number of pages17
DOIs
StatePublished - 2009

Publication series

NameMethods in Molecular Biology
Volume485
ISSN (Print)1064-3745

Keywords

  • Intrasplenic huPBL/SPL-SCID model
  • Mouse HIV-1 models
  • NOD/SCID/IL2R γ mouse model
  • Rag2γ mouse model

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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