Novel mouse models for understanding HIV-1 pathogenesis

Aviva Joseph, Kaori Sango, Harris Goldstein

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Small animal models in which in vivo HIV-1 infection, pathogenesis, and immune responses can be studied would permit both basic research on the biology of the disease, as well as a system to rapidly screen developmental therapeutics and/or vaccines. To date, the most widely-used models have been the severe combined immunodeficient (SCID)-hu (also known as the thy/liv SCID-hu) and the huPBL-SCID mouse models. Recently three new models have emerged, i.e., the intrasplenic huPBL/SPL-SCID model, the NOD/SCID/IL2Rγnull mouse model, and the $Rag2-/-γc-/- mouse model. Details on the construction, maintenance and HIV-1 infection of these models are discussed.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages311-327
Number of pages17
Volume485
DOIs
StatePublished - 2009

Publication series

NameMethods in Molecular Biology
Volume485
ISSN (Print)10643745

Fingerprint

SCID Mice
HIV Infections
HIV-1
Vaccines
Animal Models
Maintenance
Research
Therapeutics

Keywords

  • Intrasplenic huPBL/SPL-SCID model
  • Mouse HIV-1 models
  • NOD/SCID/IL2R γ mouse model
  • Rag2γ mouse model

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Joseph, A., Sango, K., & Goldstein, H. (2009). Novel mouse models for understanding HIV-1 pathogenesis. In Methods in Molecular Biology (Vol. 485, pp. 311-327). (Methods in Molecular Biology; Vol. 485). https://doi.org/10.1007/978-1-59745-170-3_21

Novel mouse models for understanding HIV-1 pathogenesis. / Joseph, Aviva; Sango, Kaori; Goldstein, Harris.

Methods in Molecular Biology. Vol. 485 2009. p. 311-327 (Methods in Molecular Biology; Vol. 485).

Research output: Chapter in Book/Report/Conference proceedingChapter

Joseph, A, Sango, K & Goldstein, H 2009, Novel mouse models for understanding HIV-1 pathogenesis. in Methods in Molecular Biology. vol. 485, Methods in Molecular Biology, vol. 485, pp. 311-327. https://doi.org/10.1007/978-1-59745-170-3_21
Joseph A, Sango K, Goldstein H. Novel mouse models for understanding HIV-1 pathogenesis. In Methods in Molecular Biology. Vol. 485. 2009. p. 311-327. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-59745-170-3_21
Joseph, Aviva ; Sango, Kaori ; Goldstein, Harris. / Novel mouse models for understanding HIV-1 pathogenesis. Methods in Molecular Biology. Vol. 485 2009. pp. 311-327 (Methods in Molecular Biology).
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