Novel mouse models for understanding HIV-1 pathogenesis

Aviva Joseph; Kaori Sango; Harris Goldstein

doi:10.1007/978-1-59745-170-3_21

Novel mouse models for understanding HIV-1 pathogenesis

Aviva Joseph, Kaori Sango, Harris Goldstein

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Small animal models in which in vivo HIV-1 infection, pathogenesis, and immune responses can be studied would permit both basic research on the biology of the disease, as well as a system to rapidly screen developmental therapeutics and/or vaccines. To date, the most widely-used models have been the severe combined immunodeficient (SCID)-hu (also known as the thy/liv SCID-hu) and the huPBL-SCID mouse models. Recently three new models have emerged, i.e., the intrasplenic huPBL/SPL-SCID model, the NOD/SCID/IL2Rγ^null mouse model, and the $Rag2^-/-γ_c^-/- mouse model. Details on the construction, maintenance and HIV-1 infection of these models are discussed.

Original language	English (US)
Title of host publication	HIV Protocols
Editors	Vinayaka R. Prasad, Ganjam V. Kalpana
Pages	311-327
Number of pages	17
DOIs	https://doi.org/10.1007/978-1-59745-170-3_21
State	Published - 2009

Publication series

Name	Methods in Molecular Biology
Volume	485
ISSN (Print)	1064-3745

Keywords

Intrasplenic huPBL/SPL-SCID model
Mouse HIV-1 models
NOD/SCID/IL2R γ mouse model
Rag2γ mouse model

ASJC Scopus subject areas

Molecular Biology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-59745-170-3_21

Cite this

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Novel mouse models for understanding HIV-1 pathogenesis

Abstract

Publication series

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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